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Details for receptor: CRF-R2

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EndoNet ID: ENR00965

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Synonyms

  • CRF-R2
  • CRF2
  • CRF-R2 alpha
  • corticotropin releasing hormone receptor 2
  • CRH-R2
  • corticotropin releasing factor receptor 2

General information

  • CRF2 mediates anxiolysis, anorexia, vasodilatation, a positive inotropic action on myocardium, and dearousal. [1]
  • CRF1 activates and CRF2 attenuates the stress responses in the central nervous system. [1]
  • CRF2 receptor is alternately spliced into three variants with similar binding properties: CRF2(a), CRF2(b), and CRF2(c). [1]
  • CRF type 1 and CRF2 were expressed in the adrenal cortex, particularly in the zonae fasciculata and reticularis but very weakly or undetectably in the medulla. [1]
  • urocortin 2 exerts its effects only in part via CRF-R2. [2]
  • CRH-R2 were expressed in the heart, lung, skeletal muscle, stomach, kidney, adrenal and placenta, in liver the expression is low. [3]

Links to other resources

UniProt Q13324
Ensembl ENST00000452278

Subunit information

CRF2-alpha

Sequence 
LAEELLLDG WGPPLDPEG PYSYCNTTL 
DQIGTCWPR SAAGALVER PCPEYFNGV 
KYNTTRNAY RECLENGTW ASKINYSQC 
EPILDDKQR KYDLHYRIA LVVNYLGHC 
VSVAALVAA FLLFLALRS IRCLRNVIH 
WNLITTFIL RNVMWFLLQ LVDHEVHES 
NEVWCRCIT TIFNYFVVT NFFWMFVEG 
CYLHTAIVM TYSTERLRK CLFLFIGWC 
IPFPIIVAW AIGKLYYEN EQCWFGKEP 
GDLVDYIYQ GPIILVLLI NFVFLFNIV 
RILMTKLRA STTSETIQY RKAVKATLV 
LLPLLGITY MLFFVNPGE DDLSQIMFI 
YFNSFLQSF QGFFVSVFY CFFNGEVRS 
AVRKRWHRW QDHHSLRVP MARAMSIPT 
SPTRISFHS IKQTAAV
UniProt Q13324-1

Binding hormones

  • urocortin-3
    • Urocortin 3 is a specific ligand for the CRF type 2 receptor. [4]
    • Ucn3 is a specific agonist for CRF2. [1]
  • CRH
  • urocortin
    • Ucn1 binds to CRF1 and CRF2. [1]
    • Ucn1 has a 40-hold higher affinity for CRF2 than CRF. [1]
  • urocortin 2

Anatomical structures with this receptor

  • cell_of_adrenal_gland_zona_reticularis

  • cell_of_adrenal_gland_zona_fasciculata

  • heart

  • lung

  • skeleton_muscle

  • stomach

  • placenta

  • pituitary_gland_of_diencephalon

    Influences

    • negative ACTH
      • Inihibition of CRH in the hypothalamus inhibts secretion of ACTH in pituritary gland [5]

  • hippocampus

  • ventromedial_nucleus_of_hypothalamus

    Influences

    • negative insulin
      • The VMH is a brain region seemingly involved in the modulation of insulin secretion as ablation of the VMH led to increase in the parasympathetic tone to the pancreas and insulin oversecretion. [6]
      • There is evidence that the CRF-R2 in the VMH mediates the anorectic effects of CRF. [7]
      • A part of insulin central effects may be mediated through its regulation of CRF-R2 VMH expression. [8]

    Induced phenotypes

    • hyperactivity of HPA axis
      • Levels of the CRF-R2 mRNA in the VMH were significantly lower in diabetic rats. Expression of CRF-R2 is mostly related to the insulin, but not to the corticosterone, status. Alterations in the brain CRF system due to insulin deficiency may contribute to the hyperdipsia in diabetes. [8]
      • Basal HPA axis may also be affected by magnocellular CRF that directly stimulates the AVP secretion through a paracrine mechanism at the level of neurohemal zone of the neurohypophysis. [8]
    • hyperphagia
      • Levels of the CRF-R2 mRNA in the VMH were significantly lower in diabetic rats. Expression of CRF-R2 is mostly related to the insulin, but not to the corticosterone, status. Alterations in the brain CRF system due to insulin deficiency may contribute to the hyperphagia in diabetes. [8]
    • hyperdipsia
      • Levels of the CRF-R2 mRNA in the VMH were significantly lower in diabetic rats. Expression of CRF-R2 is mostly related to the insulin, but not to the corticosterone, status. Alterations in the brain CRF system due to insulin deficiency may contribute to the hyperdipsia in diabetes. [8]
Reference