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Details for receptor: thyroid stimulating hormone receptor

EndoNet ID: ENR00970

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  • thyroid stimulating hormone receptor
  • TSHR
  • thyrotropin receptor
  • thyroid stimulating hormone receptor isoform 1

General information

  • Related to Graves’ disease. [1]

Links to other resources

UniProt P16473
Ensembl ENST00000412429

Binding hormones

  • GPH
  • TSH

Anatomical structures with this receptor

  • basophil_thyrotroph_cell_of_anterior_pituitary

  • thyroid_gland


    • positive T4
    • positive T3

    Induced phenotypes

    • Graves-Basedow disease
      • Graves disease is an autoimmune thyroid disease characterized by the presence of antibodies against the thyrotropin receptor (TSHR), which result in constitutive activation of the receptor and increased levels of thyroid hormone, and stimulate the thyroid to cause hyperthyroidism and/or goiter. [2]
    • Hashimoto thyroiditis
  • chondroblast

  • chondroclast