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Details for receptor: gastric inhibitory polypeptide receptor

EndoNet ID: ENR00978

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Synonyms

  • GIP-R
  • gastric inhibitory polypeptide receptor

General information

  • Control of cortisol secretion by the abnormal expression of the GIP-R have been observed in some rare cases of ACTH-independent, food-dependent Cushing’s syndrome due to adrenal adenoma or bilateral macronodular hyperplasia. [1]

Links to other resources

UniProt P48546
Ensembl ENST00000263281

Subunit information

short isoform

Sequence
RAETGSKGQ TAGELYQRW ERYRRECQE 
TLAAAEPPS GLACNGSFD MYVCWDYAA 
PNATARASC PWYLPWHHH VAAGFVLRQ 
CGSDGQWGL WRDHTQCEN PEKNEAFLD 
QRLILERLQ VMYTVGYSL SLATLLLAL 
LILSLFRRL HCTRNYIHI NLFTSFMLR 
AAAILSRDR LLPRPGPYL GDQALALWN 
QALAACRTA QIVTQYCVG ANYTWLLVE 
GVYLHSLLV LVGGSEEGH FRYYLLLGW 
GAPALFVIP WVIVRYLYE NTQCWERNE 
VKAIWWIIR TPILMTILI NFLIFIRIL 
GILLSKLRT RQMRCRDYR LRLARSTLT 
LVPLLGVHE VVFAPVTEE QARGALRFA 
KLGFEIFLS SFQGFLVSV LYCFINKEV 
QSEIRRGWH HCRLRRSLG EEQRQLPER 
AFRALPSGS GPGEVPTSR GLSSGTLPG 
PGNEASREL ESYC
UniProt P48546-1

Binding hormones

  • GIP

Anatomical structures with this receptor

  • beta_cell_of_islet_of_Langerhans

    Influences

    • positive insulin
      • siRNA-mediated knockdown of insulin receptor promoted enhanced glucagon secretion and complemented our in vivo findings [2]
      • intraislet insulin signaling plays a significant role in the regulation of alpha cell function [2]
      • insulin binding decreases the glucagon secretion [2]
      • The hormone glucose-dependent insulinotropic polypeptide (GIP) is an important regulator of insulin secretion. GIP has been shown to increase adenylyl cyclase activity, elevate intracellular Ca2+ levels, and stimulate a mitogen-activated protein kinase pathway in the pancreatic b-cell. [3]
      • Stimulation of GIP-mediated AA production was shown to be mediated via a Ca2+-independent phospholipase A2. Arachidonic acid is therefore a new component of GIP-mediated signal transduction in the b-cell. [3]
Reference