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Details for receptor: THRA1

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  • General information
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  • General information
  • Hormones
  • Anatomical structures
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EndoNet ID: ENR00982

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

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http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
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Synonyms

  • thyroid hormone receptor alpha1
  • THRA1
  • T3R-alpha1
  • NR1A1
  • TRalpha1

General information

  • TRalpha1 mRNA was expressed in the majority (> 90%) of osteoblasts. [1]
  • Expressed in lung. [2]
  • TR-alpha1 mRNA levels in HepG2 are 4-fold higher than in human primary hepatocytes and 5-fold higher than in human liver. [3]

Links to other resources

UniProt P21205
Ensembl ENST00000450525

Binding hormones

  • T3

Anatomical structures with this receptor

  • paraventricular_nucleus_of_hypothalamus

    Influences

    • negative TRH

  • brain

  • lung

  • chondrocyte

  • osteoblast

  • hepatocyte

    Influences

    • positive APOA5
      • Treatment with T3 significantly increased APOA5 mRNA levels at 6 h, and a 2-fold induction was achieved after 24 h of T3 addition. [3]

  • macrophage

Reference