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Details for receptor: galanin receptor 1

EndoNet ID: ENR00985

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Synonyms

  • GalR1
  • GALR1
  • GAL1-R
  • galanin receptor 1

General information

  • Receptor for the hormone galanin; its activity is mediated by G proteins that inhibit adenylate cyclase activity. [1]
  • human GALR1 encodes a protein of 349 amino acids with significant homology to the rhodopsin family of G-protein-coupled receptors (GPCRs) [2]

Links to other resources

UniProt P47211
Ensembl ENST00000299727

Binding hormones

  • galanin

Anatomical structures with this receptor

  • adipose_tissue

    Influences

    • negative leptin
      • Galanin inhibits ob gene expression and leptin protein secretion in vitro and in vivo. [3]
      • Galanin-induced decrease in plasma level of leptin might be mediated by inhibiting leptin release from pre-existing intracellular pool. [3]
      • Inhibitory action of galanin probably involved in GalR1 signaling, galanin-repressed leptin production may be mediated by changes in intracellular cAMP level. [3]

    Induced phenotypes

    • regulation of feeding behavior
      • Galanin mRNA expressed in visceral adipose tissue may be involved in the regulation of feeding and energy balance after fasting. [3]
  • neuron

    Induced phenotypes

    • neuroregeneration
      • Galanin induces several regulatory functions in neuronal cells, including neuroregeneration. [4]
    • modulation of sensory and behavioral functions
      • Galanin induces several regulatory functions in neuronal cells, including modulation of sensory and behavioral functions. [4]
    • neuronal growth
      • Galanin is implicated in neuronal growth. [5]
    • neuronal development
      • Galanin is implicated in neuronal development. [5]
    • apoptosis of ganglion cells
      • Loss of function of Galanin gene shows enhanced apoptosis of ganglion cells. [6]
    • regulation of exocrine and endocrine secretion
      • Galanin induces several regulatory functions in neuronal cells, including control of endocrine and exocrine secretions. [4]
    • pituitary adenoma
      • Overexpression of Galanin results in development of pituitary adenomas. [5]
  • ileum

    Induced phenotypes

    • inhibition of circular muscle contraction
      • Galanin has an inhibitory role on circular muscle contraction in ileum.
  • small_intestine

    Induced phenotypes

    • eating behavior
      • Galanin modulates food intake with a preference for fat. [7]
    • induction of smooth muscle contraction
      • Galanin induces smooth muscle contration in intestine. [7]
Reference