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Details for receptor: GR-beta

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EndoNet ID: ENR00991

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Synonyms

  • GR-beta
  • glucocorticoid receptor beta
  • NR3C1

General information

  • GR-beta mRNA abundance (×103 cDNA copies/µg total RNA) was as follows: eosinophils (1.55 ± 0.58) > PBMCs > liver >= skeletal muscle > kidney > macrophages > lung > neutrophils > brain >= nasal mucosa > heart (0.15 ± 0.08). [1]
  • GR-beta mRNA was not found in colon. [1]
  • The default splicing pathway is the one leading to GR-alpha. The alternative splicing event leading to GR-beta is minimally activated. [1]

Links to other resources

UniProt P04150
Ensembl ENST00000454007

Subunit information

beta isoform

  • No hormone-binding activity. Widely expressed at low level. Localized largely in the nucleus. [2]
Sequence 
MDSKESLTP GREENPSSV LAQERGDVM 
DFYKTLRGG ATVKVSASS PSLAVASQS 
DSKQRRLLV DFPKGSVSN AQQPDLSKA 
VSLSMGLYM GETETKVMG NDLGFPQQG 
QISLSSGET DLKLLEESI ANLNRSTSV 
PENPKSSAS TAVSAAPTE KEFPKTHSD 
VSSEQQHLK GQTGTNGGN VKLYTTDQS 
TFDILQDLE FSSGSPGKE TNESPWRSD 
LLIDENCLL SPLAGEDDS FLLEGNSNE 
DCKPLILPD TKPKIKDNG DLVLSSPSN 
VTLPQVKTE KEDFIELCT PGVIKQEKL 
GTVYCQASF PGANIIGNK MSAISVHGV 
STSGGQMYH YDMNTASLS QQQDQKPIF 
NVIPPIPVG SENWNRCQG SGDDNLTSL 
GTLNFPGRT VFSNGYSSP SMRPDVSSP 
PSSSSTATT GPPPKLCLV CSDEASGCH 
YGVLTCGSC KVFFKRAVE GQHNYLCAG 
RNDCIIDKI RRKNCPACR YRKCLQAGM 
NLEARKTKK KIKGIQQAT TGVSQETSE 
NPGNKTIVP ATLPQLTPT LVSLLEVIE 
PEVLYAGYD SSVPDSTWR IMTTLNMLG 
GRQVIAAVK WAKAIPGFR NLHLDDQMT 
LLQYSWMFL MAFALGWRS YRQSSANLL 
CFAPDLIIN EQRMTLPCM YDQCKHMLY 
VSSELHRLQ VSYEEYLCM KTLLLLSSV 
PKDGLKSQE LFDEIRMTY IKELGKAIV 
KREGNSSQN WQRFYQLTK LLDSMHENV 
MWLKPESTS HTLI
UniProt P04150-2

Binding hormones

    Anatomical structures with this receptor

    • kidney

    • lung

    • brain

    • heart

    • macrophage

    • skeleton_muscle

    • neutrophil_granulocyte

    • nasal_mucosa

    • eosinophil_granulocyte

    Reference