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Details for receptor: orexin receptor 1

EndoNet ID: ENR00993

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Synonyms

  • OX1R
  • orexin receptor 1
  • hypocretin receptor 1

General information

  • OX1R was present in acidophil cells, these cells were shown to coexpress GH. [1]
  • MCH containing neurons in the LHA expressing the ORX-R1 receptor. [2]

Links to other resources

UniProt O43613
Ensembl ENST00000455402

Subunit information

Sequence
MEPSATPGA QMGVPPGSR EPSPVPPDY 
EDEFLRYLW RDYLYPKQY EWVLIAAYV 
AVFVVALVG NTLVCLAVW RNHHMRTVT 
NYFIVNLSL ADVLVTAIC LPASLLVDI 
TESWLFGHA LCKVIPYLQ AVSVSVAVL 
TLSFIALDR WYAICHPLL FKSTARRAR 
GSILGIWAV SLAIMVPQA AVMECSSVL 
PELANRTRL FSVCDERWA DDLYPKIYH 
SCFFIVTYL APLGLMAMA YFQIFRKLW 
GRQIPGTTS ALVRNWKRP SDQLGDLEQ 
GLSGEPQPR ARAFLAEVK QMRARRKTA 
KMLMVVLLV FALCYLPIS VLNVLKRVF 
GMFRQASDR EAVYACFTF SHWLVYANS 
AANPIIYNF LSGKFREQF KAAFSCCLP 
GLGPCGSLK APSPRSSAS HKSLSLQSR 
CSISKISEH VVLTSVTTV LP

Binding hormones

  • orexin-A
    • OX1R is selective for orexin-A. [1]

Anatomical structures with this receptor

  • acidophil_somatotroph_cell_of_anterior_pituitary

  • lateral_hypothalamic_area

    Influences

    • positive orexin-B
    • orexin-A

    Induced phenotypes

    • regulation of feeding behavior
Reference