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Details for receptor: PTHR1

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EndoNet ID: ENR00999

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Synonyms

  • PTH/PTHr receptor
  • PTH/PTHrP type I receptor
  • PTHR1

General information

  • Human osteoclasts express PTH1R at the mRNA and protein level. [1]
  • This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. [2]
  • The parathyroid hormone (PTH) type 1 receptor (PTH1R) is a G protein-coupled receptor that is highly expressed in bone and kidney. [1]

Links to other resources

UniProt Q03431
Ensembl ENST00000449590

Subunit information

Sequence 
DADDVMTKE EQIFLLHRA QAQCEKRLK 
EVLQRPASI MESDKGWTS ASTSGKPRK 
DKASGKLYP ESEEDKEAP TGSRYRGRP 
CLPEWDHIL CWPLGAPGE VVAVPCPDY 
IYDFNHKGH AYRRCDRNG SWELVPGHN 
RTWANYSEC VKFLTNETR EREVFDRLG 
MIYTVGYSV SLASLTVAV LILAYFRRL 
HCTRNYIHM HLFLSFMLR AVSIFVKDA 
VLYSGATLD EAERLTEEE LRAIAQAPP 
PPATAAAGY AGCRVAVTF FLYFLATNY 
YWILVEGLY LHSLIFMAF FSEKKYLWG 
FTVFGWGLP AVFVAVWVS VRATLANTG 
CWDLSSGNK KWIIQVPIL ASIVLNFIL 
FINIVRVLA TKLRETNAG RCDTRQQYR 
KLLKSTLVL MPLFGVHYI VFMATPYTE 
VSGTLWQVQ MHYEMLFNS FQGFFVAII 
YCFCNGEVQ AEIKKSWSR WTLALDFKR 
KARSGSSSY SYGPMVSHT SVTNVGPRV 
GLGLPLSPR LLPTATTNG HPQLPGHAK 
PGTPALETL ETTPPAMAA PKDDGFLNG 
SCSGLDEEA SGPERPPAL LQEEWETVM

Binding hormones

  • TIP39
    • Unlike in peripheral tissue, TIP39 seems to be the single probable ligand of this receptor in brain. [3]
    • TIP39 did bind to P1R with moderate affinity, but showed higher affinity binding to P2R. [3]
  • PTHLH
  • PTH
    • PTH activates PTHR by interacting with a ligand-binding site localized within the N-terminal extracellular domain (the Ndomain) and the domain comprising the seven transmembrane helices and the connecting extracellular loops (the J-domain). [4]
    • PTH acts on the kidney to regulate VD3 (calcitriol) synthesis. [5]
    • PTH acts on cells of the osteoblast lineage to stimulate both bone formation and resorbtion. [5]

Anatomical structures with this receptor

  • osteoclast

  • kidney

    Influences

    • positive calcitriol

    Induced phenotypes

    • phosphate ion homeostasis
      • The homeostasis of serum Pi levels is effected through a complex interplay between intestinal absorption, exchange with intracellular and bone storage pools, and renal tubular reabsorption. [6]
      • These processes are primarily regulated by parathyroid hormone (PTH). [7]
    • familial isolated hypoparathyroidism
      • Familial isolated hypoparathyroidism can be caused by mutation in the parathyroid hormone gene. [8]
    • Primary hyperparathyroidism
      • Primary hyperparathyroidism is a relatively common endocrine disorder caused by abnormal regulation and hyper‐secretion of parathyroid hormone (PTH) from the parathyroid glands. [9]

  • osteoblast

    Influences

    • positive RANKL
    • positive M-CSF
      • Stromal cells and osteoblasts express RANKL and M-CSF, which are up-regulated by osteoclastogenic molecules such as PTH. [10]
    • positive interleukin 6
      • Il-6 is produced by osteoblasts, and its production is stimulated by PTH and PGE2. [11]
    • positive amphiregulin
      • PTH rapidly and strongly stimulates the expression of amphiregulin not only in several osteoblastic cell lines but also in bone. [12]

  • hematopoietic_stem_cell

    Influences

    • positive RANKL

  • stromal_cell_of_bone_marrow

    Influences

    • positive RANKL
      • Stromal cells and osteoblasts express RANKL and M-CSF, which are up-regulated by osteoclastogenic molecules such as PTH. [10]
    • positive M-CSF
      • Stromal cells and osteoblasts express RANKL and M-CSF, which are up-regulated by osteoclastogenic molecules such as PTH. [10]

  • chondrocyte

Reference