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Details for receptor: ErbB4

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  • General information
  • Subunits
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  • Hormones
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EndoNet ID: ENR01000

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For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

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Synonyms

  • ErbB4
  • p180erbB4
  • HER4

General information

  • Specifically binds and is activated by neuregulins, NRG-2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. Interaction with these factors induces cell differenciation. Not activated by EGF, TGF-A, and amphiregulin. [1]
  • Activation of ErbB receptors is important for the regulation of cell proliferation, differentiation, and survival. Binding of specific ligand to one of the ErbB receptors triggers the formation of specific receptor homo- and heterodimers, with ErbB2 beeing the preferred signaling partner. [2]

Links to other resources

UniProt Q15303
Ensembl ENST00000436443

Subunit information

Sequence 
QSVCAGTEN KLSSLSDLE QQYRALRKY 
YENCEVVMG NLEITSIEH NRDLSFLRS 
VREVTGYVL VALNQFRYL PLENLRIIR 
GTKLYEDRY ALAIFLNYR KDGNFGLQE 
LGLKNLTEI LNGGVYVDQ NKFLCYADT 
IHWQDIVRN PWPSNLTLV STNGSSGCG 
RCHKSCTGR CWGPTENHC QTLTRTVCA 
EQCDGRCYG PYVSDCCHR ECAGGCSGP 
KDTDCFACM NFNDSGACV TQCPQTFVY 
NPTTFQLEH NFNAKYTYG AFCVKKCPH 
NFVVDSSSC VRACPSSKM EVEENGIKM 
CKPCTDICP KACDGIGTG SLMSAQTVD 
SSNIDKFIN CTKINGNLI FLVTGIHGD 
PYNAIEAID PEKLNVFRT VREITGFLN 
IQSWPPNMT DFSVFSNLV TIGGRVLYS 
GLSLLILKQ QGITSLQFQ SLKEISAGN 
IYITDNSNL CYYHTINWT TLFSTINQR 
IVIRDNRKA ENCTAEGMV CNHLCSSDG 
CWGPGPDQC LSCRRFSRG RICIESCNL 
YDGEFREFE NGSICVECD PQCEKMEDG 
LLTCHGPGP DNCTKCSHF KDGPNCVEK 
CPDGLQGAN SFIFKYADP DRECHPCHP 
NCTQGCNGP TSHDCIYYP WTGHSTLPQ 
HARTPLIAA GVIGGLFIL VIVGLTFAV 
YVRRKSIKK KRALRRFLE TELVEPLTP 
SGTAPNQAQ LRILKETEL KRVKVLGSG 
AFGTVYKGI WVPEGETVK IPVAIKILN 
ETTGPKANV EFMDEALIM ASMDHPHLV 
RLLGVCLSP TIQLVTQLM PHGCLLEYV 
HEHKDNIGS QLLLNWCVQ IAKGMMYLE 
ERRLVHRDL AARNVLVKS PNHVKITDF 
GLARLLEGD EKEYNADGG KMPIKWMAL 
ECIHYRKFT HQSDVWSYG VTIWELMTF 
GGKPYDGIP TREIPDLLE KGERLPQPP 
ICTIDVYMV MVKCWMIDA DSRPKFKEL 
AAEFSRMAR DPQRYLVIQ GDDRMKLPS 
PNDSKFFQN LLDEEDLED MMDAEEYLV 
PQAFNIPPP IYTSRARID SNRSEIGHS 
PPPAYTPMS GNQFVYRDG GFAAEQGVS 
VPYRAPTST IPEAPVAQG ATAEIFDDS 
CCNGTLRKP VAPHVQEDS STQRYSADP 
TVFAPERSP RGELDEEGY MTPMRDKPK 
QEYLNPVEE NPFVSRRKN GDLQALDNP 
EYHNASNGP PKAEDEYVN EPLYLNTFA 
NTLGKAEYL KNNILSMPE KAKKAFDNP 
DYWNHSLPP RSTLQHPDY LQEYSTKYF 
YKQNGRIRP IVAENPEYL SEFSLKPGT 
VLPPPPYRH RNTVV

Binding hormones

  • neuregulin-2
    • NRG-2 is a ligand for ERBB3 and ERBB4 tyrosine kinase receptors. [1]
  • betacellulin
  • NRG-3
  • NRG1-beta1
  • NRG1-beta3
  • EPR
  • neuregulin 1 isoform SMDF
  • NRG-1
  • HB-EGF
  • NRG-4

Anatomical structures with this receptor

    Reference