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Details for receptor: SHBG-R

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EndoNet ID: ENR01002

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Synonyms

  • Testosterone-estrpgem-binding globulin
  • Sex steroid-binding protein
  • SHBG-R
  • Sex hormone-binding globulin receptor
  • Rshbg

General information

  • SHBG cannot bind to its receptor if it is already bound to a steroid (whether an agonist or antagonist). SHBG must first bind to RSHBG forming SHBG-RSHBG and the steroid must bind to that complex. [1]
  • SHGB binds with high affinity to a specific membrane receptor (RSHBG) in prostate stromal and epithelial cells, wherein the SHBG:RSHBG complex forms. [1]
  • Sex hormone-binding globulin (SHBG) (..) binds estrogens and androgens and (..) regulates the free concentration of the steroids that bind to it. Additionally it participates in signal transduction for certain steroid hormones at the cell membrane (and) binds with high affinity to a specific membrane receptor RSHBG (...)wherein the SHBG:RSHBG complex forms [2]
  • Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific fpr 5-alpha-dihydrotestosterone, testosterone and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.

Links to other resources

UniProt P04278
Ensembl ENST00000380450

Subunit information

SHBG (1 times)

  • Sex hormone-binding globulin is a plasma glycoprotein that binds certain estrogens and androgens with high affinity. [3]
  • Sex hormone-binding globulin (SHBG) is a plasma protein synthesized and secreted by the liver. [1]
  • SHGB has two disparate functions: regulation of the concentration of free steroids in plasma and signal transduction in selected tissues. [1]
  • The liver synthesizes and secretes SHBG into the plasma. [1]
  • In women (in plasma) about 50% of SHBG is not bound to steroids and in men unbound SHBG constitutes about 20%. [1]
Sequence 
LRPVLPTQS AHDPPAVHL SNGPGQEPI 
AVMTFDLTK ITKTSSSFE VRTWDPEGV 
IFYGDTNPK DDWFMLGLR DGRPEIQLH 
NHWAQLTVG AGPRLDDGR WHQVEVKME 
GDSVLLEVD GEEVLRLRQ VSGPLTSKR 
HPIMRIALG GLLFPASNL RLPLVPALD 
GCLRRDSWL DKQAEISAS APTSLRSCD 
VESNPGIFL PPGTQAEFN LRDIPQPHA 
EPWAFSLDL GLKQAAGSG HLLALGTPE 
NPSWLSLHL QDQKVVLSS GSGPGLDLP 
LVLGLPLQL KLSMSRVVL SQGSKMKAL 
ALPPLGLAP LLNLWAKPQ GRLFLGALP 
GEDSSTSFC LNGLWAQGQ RLDVDQALN 
RSHEIWTHS CPQSPGNGT DASH
UniProt P04278

SHBG-R (1 times)

Binding hormones

  • 5alpha-androstanediol
  • DHT
  • estradiol
  • testosterone

Anatomical structures with this receptor

  • prostate

    Influences

    • positive free PSA
      • The gene for prostate-specific antigen (PSA) contains an androgen response element. After binding its cognate ligand, the androgen receptor (AR) interacts with this response element to initiate PSA mRNA transcription and secretion. In the absence of androgens, E2 in concert with SHBG-RSHBG, acts at the cell membrane to cause secretion of PSA and that this effect is blocked by anti-androgens. [4]
    • SHBG binds with high affinity to a specofoc membrane receptor (RSHBG) in prostate stromal and epithelial cells. [2]
Reference