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Details for receptor: ALK7

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EndoNet ID: ENR01003

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Synonyms

  • ALK7
  • activin receptor type 1C
  • ACTR-IC
  • activin receptor-like kinase 7
  • ALK-7
  • ACVRLK7
  • ACVR1C

General information

  • Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells. [1]
  • Plays a role in cell differentiation, growth arrest and apoptosis. [2]
  • Receptor for activin AB, activin B and NODAL. [2]

Links to other resources

UniProt Q8NER5
Ensembl ENST00000409680

Subunit information

Sequence 
ELSPGLKCV CLLCDSSNF TCQTEGACW 
ASVMLTNGK EQVIKSCVS LPELNAQVF 
CHSSNNVTK TECCFTDFC NNITLHLPT 
ASPNAPKLG PMELAIIIT VPVCLLSIA 
AMLTVWACQ GRQCSYRKK KRPNVEEPL 
SECNLVNAG KTLKDLIYD VTASGSGSG 
LPLLVQRTI ARTIVLQEI VGKGRFGEV 
WHGRWCGED VAVKIFSSR DERSWFREA 
EIYQTVMLR HENILGFIA ADNKDNGTW 
TQLWLVSEY HEQGSLYDY LNRNIVTVA 
GMIKLALSI ASGLAHLHM EIVGTQGKP 
AIAHRDIKS KNILVKKCE TCAIADLGL 
AVKHDSILN TIDIPQNPK VGTKRYMAP 
EMLDDTMNV NIFESFKRA DIYSVGLVY 
WEIARRCSV GGIVEEYQL PYYDMVPSD 
PSIEEMRKV VCDQKFRPS IPNQWQSCE 
ALRVMGRIM RECWYANGA ARLTALRIK 
KTISQLCVK EDCKA

Binding hormones

  • NODAL
  • activin AB
  • activin B
  • GDF-3
    • We also demonstrate that GDF3 can signal via the ALK4-homolog ALK7 and the coreceptor Cripto, both of which are expressed in adipose tissue. [3]
  • GDF-1

Anatomical structures with this receptor

  • adipose_tissue

    Induced phenotypes

    • regulation of adipose-tissue homeostasis
      • We propose that GDF3 regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the ALK7 receptor. [3]
    • Expression of activin receptor-like kinase 7 (ALK7) was adipose tissue specific. [4]
Reference