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Details for receptor: ferroportin-1

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EndoNet ID: ENR01004

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Synonyms

  • MTP1
  • ferroportin-1
  • iron-regulated transporter 1
  • FPN1
  • IREG1
  • SLC40A1

General information

  • Two metal transporters, the divalent metal transporter-1 (DMT1) and the ferroportin/Ireg1 were shown to be expressed in the basal membrane (of the placenta) and these might play a role in iron transport to the fetus. [1]
  • Iron export from enterocytes is mediated by ferroportin1 together with the ferrooxidase hephaestin, which oxidizes iron to its ferric state for transport in the serum bound to transferrin. [2]
  • Iron is stored in the liver in both hepatocytes and liver macrophages (Kupffer cells). Both cell types express ferroportin to release iron into the circulation and thus are potential targets for hepcidin. [2]

Links to other resources

UniProt Q9NP59
Ensembl ENST00000455320

Binding hormones

  • hepcidin
    • Hepcidin binds to FPN1 to enhance FPN1 internalisation and degradation and thus diminishes iron release. [2]
    • FPN1 is expressed in macrophages, hepatocytes and intestinal enterocytes, hepcidin is expected to block iron export from these tissues. [2]

Anatomical structures with this receptor

  • duodenal_enterocyte

  • macrophage

  • hepatocyte

  • Kupffer_cell_stellate_cell_of_liver

  • placenta

Reference