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Details for receptor: transferrin receptor 1

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EndoNet ID: ENR01007

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Synonyms

  • transferrin receptor
  • TFRC
  • CD71
  • Trfr
  • T9
  • p90
  • transferrin receptor 1
  • TFR1
  • Transferrin receptor protein 1

General information

  • Transferrin receptor is necessary for development of erythrocytes and the nervous system. [1]
  • Heme iron is recycled on ingestion of senescent erythrocytes by reticuloendothelial (RE) macrophages. Macrophages also express surface TfRs and take up iron from the circulation directly. [2]

Links to other resources

UniProt P02786
Ensembl ENST00000426789

Subunit information

Sequence 
MMDQARSAF SNLFGGEPL SYTRFSLAR 
QVDGDNSHV EMKLAVDEE ENADNNTKA 
NVTKPKRCS GSICYGTIA VIVFFLIGF 
MIGYLGYCK GVEPKTECE RLAGTESPV 
REEPGEDFP AARRLYWDD LKRKLSEKL 
DSTDFTSTI KLLNENSYV PREAGSQKD 
ENLALYVEN QFREFKLSK VWRDQHFVK 
IQVKDSAQN SVIIVDKNG RLVYLVENP 
GGYVAYSKA ATVTGKLVH ANFGTKKDF 
EDLYTPVNG SIVIVRAGK ITFAEKVAN 
AESLNAIGV LIYMDQTKF PIVNAELSF 
FGHAHLGTG DPYTPGFPS FNHTQFPPS 
RSSGLPNIP VQTISRAAA EKLFGNMEG 
DCPSDWKTD STCRMVTSE SKNVKLTVS 
NVLKEIKIL NIFGVIKGF VEPDHYVVV 
GAQRDAWGP GAAKSGVGT ALLLKLAQM 
FSDMVLKDG FQPSRSIIF ASWSAGDFG 
SVGATEWLE GYLSSLHLK AFTYINLDK 
AVLGTSNFK VSASPLLYT LIEKTMQNV 
KHPVTGQFL YQDSNWASK VEKLTLDNA 
AFPFLAYSG IPAVSFCFC EDTDYPYLG 
TTMDTYKEL IERIPELNK VARAAAEVA 
GQFVIKLTH DVELNLDYE RYNSQLLSF 
VRDLNQYRA DIKEMGLSL QWLYSARGD 
FFRATSRLT TDFGNAEKT DRFVMKKLN 
DRVMRVEYH FLSPYVSPK ESPFRHVFW 
GSGSHTLPA LLENLKLRK QNNGAFNET 
LFRNQLALA TWTIQGAAN ALSGDVWDI 
DNEF

Binding hormones

  • Serotransferrin
    (trough: serum
    )
    • soluble transferrin receptor
    • serum form is only glycosylated

Anatomical structures with this receptor

  • cell_of_syncytiotrophoblast

    Induced phenotypes

    • regulation of iron ion transmembrane transport
      • A developing fetus needs a lot of iron, which is transferred across the human placenta. Iron uptake at the apical membrane of the syncytiotrophoblast occurs via TfR-mediated endocytosis of maternal iron. [3]
      • Hemochromatosis factor regulates TfR-mediated iron uptake. TfR and hemochromatosis factor, as well as TfR and divalent metal transporter-1 interact in placental trophoblast cells. [4]

  • hepatocyte

    Induced phenotypes

    • regulation of iron ion transmembrane transport
      • Absorbed iron is bound to circulating transferrin and passes initially through the portal system of the liver, which is the major site of iron storage. Hepatocytes take up transferrin-bound iron via the classical transferrin receptor (TfR1) but likely in greater amounts by the homologous protein, TfR2. [2]
Reference