Details for receptor: T-cadherin

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General information
Hormones
Anatomical structures
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EndoNet ID: ENR01008

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Synonyms

atypical lipoprotein-binding protein
T-cadherin
P105
cadherin-13
cadherin 13
CDH13
H-cadherin
CDHH
truncated-cadherin
heart-cadherin
T-cad
H cadherin

General information

T-cadherin is a glycosylphosphatidylinositol-anchored extracellular protein, it may act as a coreceptor for an as-yet-unidentified signaling receptor through which adiponectin transmits metabolic signals. [1]
T-cadherin is a receptor for the hexameric and high-molecular-weight species of adiponectin but not for the trimeric or globular species. [1]
T-cadherin is expressed in endothelial and smooth muscle cells, where it is positioned to interact with adiponectin. [1]
T-Cadherin binds Adiponectin and is necessary for Adiponectin-mediated cardioprotection in mice [2]

Links to other resources

UniProt	P55290
Ensembl	ENST00000446376

Subunit information

truncated (t-) Cadherin lacks transmembrane and cytoplasmic regions and is attached instead to the plasma membrane via a GPI moiety [3]

Sequence

MQPRTPLVL CVLLSQVLL LTSAEDLDC 
TPGFQQKVF HINQPAEFI EDQSILNLT 
FSDCKGNDK LRYEVSSPY FKVNSDGGL 
VALRNITAV GKTLFVHAR TPHAEDMAE 
LVIVGGKDI QGSLQDIFK FARTSPVPR 
QKRSIVVSP ILIPENQRQ PFPRDVGKV 
VDSDRPERS KFRLTGKGV DQEPKGIFR 
INENTGSVS VTRTLDREV IAVYQLFVE 
TTDVNGKTL EGPVPLEVI VIDQNDNRP 
IFREGPYIG HVMEGSPTG TTVMRMTAF 
DADDPATDN ALLRYNIRQ QTPDKPSPN 
MFYIDPEKG DIVTVVSPA LLDRETLEN 
PKYELIIEA QDMAGLDVG LTGTATATI 
MIDDKNDHS PKFTKKEFQ ATVEEGAVG 
VIVNLTVED KDDPTTGAW RAAYTIING 
NPGQSFEIH TNPQTNEGM LSVVKPLDY 
EISAFHTLL IKVENEDPL VPDVSYGPS 
STATVHITV LDVNEGPVF YPDPMMVTR 
QEDLSVGSV LLTVNATDP DSLQHQTIR 
YSVYKDPAG WLNINPING TVDTTAVLD 
RESPFVDNS VYTALFLAI DSGNPPATG 
TGTLLITLE DVNDNAPFI YPTVAEVCD 
DAKNLSVVI LGASDKDLH PNTDPFKFE 
IHKQAVPDK VWKISKINN THALVSLLQ 
NLNKANYNL PIMVTDSGK PPMTNITDL 
RVQVCSCRN SKVDCNAAG ALRFSLPSV 
LLLSLFSLA CL

UniProt

P55290

Binding hormones

Anatomical structures with this receptor

Reference

EndoNet

The information resource about the endocrine network in human.