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Details for receptor: 5-HT3 receptor

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EndoNet ID: ENR01012

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Synonyms

  • 5-HT3 receptor
  • serotonin 5-HT3 receptor
  • 5-hydroxytryptamine receptor 3
  • 5-hydroxytryptamine receptor 3A
  • HTR3
  • HTR3A
  • serotonin-gated ion channel receptor
  • 5-HT3R
  • 5HT3R

General information

  • Cation channel. [1]
  • Alternative splicing.

Links to other resources

UniProt P46098
Ensembl ENST00000375498

Subunit information

5-hydroxytryptamine 3 receptor

Sequence 
RRSRNTTRP ALLRLSDYL LTNYRKGVR 
PVRDWRKPT TVSIDVIVY AILNVDEKN 
QVLTTYIWY RQYWTDEFL QWNPEDFDN 
ITKLSIPTD SIWVPDILI NEFVDVGKS 
PNIPYVYIR HQGEVQNYK PLQVVTACS 
LDIYNFPFD VQNCSLTFT SWLHTIQDI 
NISLWRLPE KVKSDRSVF MNQGEWELL 
GVLPYFREF SMESSNYYA EMKFYVVIR 
RRPLFYVVS LLLPSIFLM VMDIVGFYL 
PPNSGERVS FKITLLLGY SVFLIIVSD 
TLPATAIGT PLIGVYFVV CMALLVISL 
AETIFIVRL VHKQDLQQP VPAWLRHLV 
LERIAWLLC LREQSTSQR PPATSQATK 
TDDCSAMGN HCSHMGGPQ DFEKSPRDR 
CSPPPPPRE ASLAVCGLL QELSSIRQF 
LEKRDEIRE VARDWLRVG SVLDKLLFH 
IYLLAVLAY SITLVMLWS IWQYA

Binding hormones

  • serotonin
    • Serotonin acts as ligand of the 5-HT-3 receptor and facilitate the function of the ligand-gate channels.

Anatomical structures with this receptor

  • hippocampus

    Influences

    • positive acetylcholine
      • Increasing of hippocampal ACh release is mediated via serotonin activation of 5-HT-3 serotonergic receptors in the dorsal hippocampus. [2]
    • norepinephrine
      • The activation of 5-HT-3 receptors mediate increased potassium- evoked release of noradrenalin from preloaded slice of rabbit hippocampus. [3]

  • amygdaloid_body

    Influences

    • positive GABA
      • Activation of presynaptic 5-HT-3 receptors facilitate synaptic GABA release from GABAergic presynaptic nerve terminals in the amygdala. [4]
    • Activation of presynaptic 5-HT-3 receptors facilitate synaptic GABA release from GABAergic presynaptic nerve terminals in the amygdala. [4]

  • frontal_lobe

    Influences

    • negative acetylcholine
      • Acitvated 5-HT-3 receptors decreases the potassium-evoked release of acetycholine in slices of the central cortex. [5]
    • positive cholecystokinin
      • 5-HT mediated activation of 5-HT-3 receptors enhance the release of cholecystokinin in synaptosomes of the rat nucleus accumbens and cerebral cortex. [6]

  • area_postrema_of_pons

  • glial_cell_of_peripheral_nervous_system

  • nucleus_accumbens

    Influences

    • positive dopamine
      • Stimulation of 5-HT-3 receptors mediate a dose-dopendent increase of DA release. [7]
Reference