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Details for receptor: thrombospondin receptor

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EndoNet ID: ENR01018

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Synonyms

  • thrombospondin receptor
  • GPIV
  • glycoprotein IIIb
  • GPIIIB
  • leukocyte differentiation antigen CD36
  • CD36 antigen
  • CD36
  • PAS IV
  • PAS-4 protein
  • platelet collagen receptor
  • fatty acid translocase
  • FAT
  • GP3B
  • GP4
  • collagen type I receptor
  • platelet glycoprotein IV
  • scavenger receptor class B, member 3
  • thrombospondin membrane receptor

General information

  • The cell-surface glycoprotein CD36 interacts with a large variety of ligands, including collagen types I and IV, thrombospondin, erythrocytes parasitized with Plasmodium falciparum, platelet-agglutinating protein p37, oxidized low density lipoprotein, and long-chain fatty acids. [1]
  • 88-kd membrane glycoprotein present in platelets, endothelial cells, monocytes, and a variety of human tumor cell lines that is the membrane binding site for TSP. [2]
  • CD36 polymorphism is associated with protection from cerebral malaria. [3]
  • Normal human erythrocytes express CD36, an adhesion molecule of monocytes, platelets, and endothelial cells. [4]

Links to other resources

UniProt P16671
Ensembl ENST00000447544

Subunit information

Platelet glycoprotein IV, chain

Sequence 
GCDRNCGLI AGAVIGAVL AVFGGILMP 
VGDLLIQKT IKKQVVLEE GTIAFKNWV 
KTGTEVYRQ FWIFDVQNP QEVMMNSSN 
IQVKQRGPY TYRVRFLAK ENVTQDAED 
NTVSFLQPN GAIFEPSLS VGTEADNFT 
VLNLAVAAA SHIYQNQFV QMILNSLIN 
KSKSSMFQV RTLRELLWG YRDPFLSLV 
PYPVTTTVG LFYPYNNTA DGVYKVFNG 
KDNISKVAI IDTYKGKRN LSYWESHCD 
MINGTDAAS FPPFVEKSQ VLQFFSSDI 
CRSIYAVFE SDVNLKGIP VYRFVLPSK 
AFASPVENP DNYCFCTEK IISKNCTSY 
GVLDISKCK EGRPVYISL PHFLYASPD 
VSEPIDGLN PNEEEHRTY LDIEPITGF 
TLQFAKRLQ VNLLVKPSE KIQVLKNLK 
RNYIVPILW LNETGTIGD EKANMFRSQ 
VTGKINLLG LIEMILLSV GVVMFVAFM 
ISYCACRSK TIK
UniProt P16671

CD36 antigen

Sequence 
MGCDRNCGL IAGAVIGAV LAVFGGILM 
PVGDLLIQK TIKKQVVLE EGTIAFKNW 
VKTGTEVYR QFWIFDVQN PQEVMMNSS 
NIQVKQRGP YTYRVRFLA KENVTQDAE 
DNTVSFLQP NGAIFEPSL SVGTEADNF 
TVLNLAVAA ASHIYQNQF VQMILNSLI 
NKSKSSMFQ VRTLRELLW GYRDPFLSL 
VPYPVTTTV GLFYPYNNT ADGVYKVFN 
GKDNISKVA IIDTYKGKR NLSYWESHC 
DMINGTDAA SFPPFVEKS QVLQFFSSD 
ICRSIYAVF ESDVNLKGI PVYRFVLPS 
KAFASPVEN PDNYCFCTE KIISKNCTS 
YGVLDISKC KEGRPVYIS LPHFLYASP 
DVSEPIDGL NPNEEEHRT YLDIEPITG 
FTLQFAKRL QVNLLVKPS EKIQVLKNL 
KRNYIVPIL WLNETGTIG DEKANMFRS 
QVTGKINLL GLIEMILLS VGVVMFVAF 
MISYCACRS KTIK

Binding hormones

  • apo B-100
  • apo B-48
  • thrombospondin 1

Anatomical structures with this receptor

  • platelet

    Induced phenotypes

    • regulation of cell adhesion
      • CD36, identified as a platelet integral membrane glycoprotein, is known as a receptor for thrombospondin-1, which is found in platelets alpha granules and participates in cell attachment. [5]

  • monocyte

    Induced phenotypes

    • positive regulation of macrophage derived foam cell
      • CD36 binds LDL that has been exposed to "minimally" oxidizing conditions. [6]
      • CD36 has a critical role in monocyte/macrophage foam cell formation and atherosclerosis. [5]

  • continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

    Induced phenotypes

    • negative regulation of angiogenesis
      • CD36 mediates the antiangiogenic signal of TSP-1. [7]

  • cytotrophoblast

  • placenta

  • skeleton_muscle

    Induced phenotypes

    • lipid homeostasis
      • Transgenic mice that overexpresses Cd36 in heart and skeletal muscle showed reduction in blood triglycerides and non-esterified fatty acids establishing a physiological role for Cd36 in whole-body lipid homeostasis. [8]

  • fat_cell

    Induced phenotypes

    • transport of long-chain fatty acids
      • CD36 is a fatty acid translocase necessary for the transport of long-chain fatty acids. [9]

  • bone_marrow

  • blood_vessel

  • cell_of_endometrium_of_uterus

  • adipose_tissue

    Induced phenotypes

    • transport of long-chain fatty acids
      • CD36 is a fatty acid translocase necessary for the transport of long-chain fatty acids. [9]
Reference