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Details for receptor: BMP receptor type II

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EndoNet ID: ENR01025

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Synonyms

  • BMPR II
  • BMP receptor type II
  • BMPR2
  • BR2
  • BMP receptor 2
  • bone morphogenetic protein receptor type II
  • BMP type II receptor
  • BMPR-II
  • PPH1

General information

  • Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. [1]
  • BMP-7 expression is absent in the liver, but the receptors for BMP-7 are present on adult hepatocytes. [2]
  • Single-pass membrane receptor type I.
  • Highly expressed in heart and liver. [1]
  • Transcription of BMP-2, BMP-3, BMP-4, BMP-5, and BMP-7 and receptors of BMPR-IA, BMPR-IB and BMPR-II was detected in ex vivo and cultured corneal epithelium and stroma. [3]

Links to other resources

UniProt Q13873
Ensembl ENST00000445231

Subunit information

Bone morphogenetic protein receptor type-2 (chain)

Sequence 
SQNQERLCA FKDPYQQDL GIGESRISH 
ENGTILCSK GSTCYGLWE KSKGDINLV 
KQGCWSHIG DPQECHYEE CVVTTTPPS 
IQNGTYRFC CCSTDLCNV NFTENFPPP 
DTTPLSPPH SFNRDETII IALASVSVL 
AVLIVALCF GYRMLTGDR KQGLHSMNM 
MEAAASEPS LDLDNLKLL ELIGRGRYG 
AVYKGSLDE RPVAVKVFS FANRQNFIN 
EKNIYRVPL MEHDNIARF IVGDERVTA 
DGRMEYLLV MEYYPNGSL CKYLSLHTS 
DWVSSCRLA HSVTRGLAY LHTELPRGD 
HYKPAISHR DLNSRNVLV KNDGTCVIS 
DFGLSMRLT GNRLVRPGE EDNAAISEV 
GTIRYMAPE VLEGAVNLR DCESALKQV 
DMYALGLIY WEIFMRCTD LFPGESVPE 
YQMAFQTEV GNHPTFEDM QVLVSREKQ 
RPKFPEAWK ENSLAVRSL KETIEDCWD 
QDAEARLTA QCAEERMAE LMMIWERNK 
SVSPTVNPM STAMQNERN LSHNRRVPK 
IGPYPDYSS SSYIEDSIH HTDSIVKNI 
SSEHSMSST PLTIGEKNR NSINYERQQ 
AQARIPSPE TSVTSLSTN TTTTNTTGL 
TPSTGMTTI SEMPYPDET NLHTTNVAQ 
SIGPTPVCL QLTEEDLET NKLDPKEVD 
KNLKESSDE NLMEHSLKQ FSGPDPLSS 
TSSSLLYPL IKLAVEATG QQDFTQTAN 
GQACLIPDV LPTQIYPLP KQQNLPKRP 
TSLPLNTKN STKEPRLKF GSKHKSNLK 
QVETGVAKM NTINAAEPH VVTVTMNGV 
AGRNHSVNS HAATTQYAN GTVLSGQTT 
NIVTHRAQE MLQNQFIGE DTRLNINSS 
PDEHEPLLR REQQAGHDE GVLDRLVDR 
RERPLEGGR TNSNNNNSN PCSEQDVLA 
QGVPSTAAD PGPSKPRRA QRPNSLDLS 
ATNVLDGSS IQIGESTQD GKSGSGEKI 
KKRVKTPYS LKRWRPSTW VISTESLDC 
EVNNNGSNR AVHSKSSTA VYLAEGGTA 
TTMVSKDIG MNCL
UniProt Q13873

Binding hormones

  • BMP2
  • BMP4
  • BMP7
  • GDF-9
    • In combination with the use of antisense BMPRII oligomers, we found that BMPRII is essential for GDF-9 signaling in granulosa cells and that the BMPRII ectodomain directly interacts with GDF-9 and completely blocks GDF-9 actions. [4]
    • Bone morphogenetic protein receptor type II is a receptor for growth differentiation factor-9. [4]
  • GDF-6
    • The present findings indicate that BMPRII and ALK3 are receptors for GDF6. [5]
  • BMP6
    • BMP-6 strongly bound to activin receptor-like kinase (ALK)-2 (also termed ActR-I), together with type II receptors, i.e. BMP type II receptor (BMPR-II) and activin type II receptor (ActR-II). [6]

Anatomical structures with this receptor

  • skin

  • fibroblast

  • heart

  • hepatocyte

  • adrenal_medulla

    Induced phenotypes

    • regulation of cell fate specification
      • In addition to the developmental context, BMPs secreted locally by the adrenal cortex are good candidates that could also modify the cellular fate of tissue progenitor cells in the adult adrenal medulla. [7]
    • negative regulation of catecholamine biosynthetic process
      • BMPs have the potential to influence aldosterone-dependent dopamine production. [8]
      • BMPs are thought to influence catecholamine production of adrenomedullary cells via an indirect mechanism through interfering with steroid hormone-dependent signalling pathways. [9]
      • BMPs can inhibit dopamine expression and reduced DOPA decarboxylase mRNA expression in a dose-dependent manner, thereby acting antagonistic to glucocorticoids. [9]

  • adrenal_cortex

    Influences

    • positive aldosterone
      • In vitro experiments in NCIh295R adrenocortical tumour cells have revealed BMP-6-induced and SMAD1/SMAD5/SMAD8-mediated augmentation of aldosterone secretion through a crosstalk with Ang II-dependent pathways. [10]
      • Potassium-induced aldosterone production was not found to be influenced by BMP-6. [7]
    • negative aldosterone
      • Specifically, secretion of aldosterone, was reduced by BMP-2 and BMP-5 in a dose-dependent manner. [11]
      • In contrast to BMP-6, it could be recently demonstrated that both BMP-2 and BMP-5 are able to overall suppress forskolin-induced steroidogenesis in NCIh295R cells. [11]
    • negative cortisol
      • In contrast to BMP-6, it could be recently demonstrated that both BMP-2 and BMP-5 are able to overall suppress forskolin-induced steroidogenesis in NCIh295R cells. [11]
      • Specifically, secretion of cortisol, was reduced by BMP-2 and BMP-5 in a dose-dependent manner. [11]

    Induced phenotypes

    • negative regulation of steroid hormone biosynthetic
      • In contrast to BMP-6, it recently could be demonstrated that both BMP-2 and BMP-5 are able to overall suppress forskolin-induced steroidogenesis in NCIh295R cells. [11]
      • Specifically, secretion of aldosterone, cortisol, and dehydroepiandrosterone-sulphate, was reduced by BMP-2 and BMP-5 in a dose-dependent manner. [11]
    • regulation of steroid biosynthetic process
      • Endogenous BMP-6 produced by adrenocortical cells could play an important autocrine role in modulating the steroidogenic actions of Ang II. [7]
    • negative regulation of adrenocorticotropin receptor activity
      • Expression levels of several steroidogenic enzymes, catalyzing the different steps of hormone production, as well as the ACTH receptor (melanocortin 2 receptor), were also inhibited by BMP-2 and BMP-5 treatment in a dose- and time-dependent manner. [11]
Reference