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Details for receptor: BMP receptor type 1A

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  • Hormones
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EndoNet ID: ENR01026

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Synonyms

  • BMPR1A
  • bone morphogenetic protein receptor type IA
  • serine/threonine-protein kinase receptor R5
  • BMP receptor type 1A
  • SKR5
  • activin receptor-like kinase 3
  • ALK-3
  • CD292 antigen
  • ACVRLK3
  • BMP receptor type IA
  • BR1a
  • BMPR-IA
  • bone morphogenetic protein receptor (type IA)
  • bone morphogenetic protein receptor, type IA

General information

  • Single-pass membrane receptor type I.

Links to other resources

UniProt P36894
Ensembl ENST00000372037

Subunit information

Sequence 
QNLDSMLHG TGMKSDSDQ KKSENGVTL 
APEDTLPFL KCYCSGHCP DDAINNTCI 
TNGHCFAII EEDDQGETT LASGCMKYE 
GSDFQCKDS PKAQLRRTI ECCRTNLCN 
QYLQPTLPP VVIGPFFDG SIRWLVLLI 
SMAVCIIAM IIFSSCFCY KHYCKSISS 
RRRYNRDLE QDEAFIPVG ESLKDLIDQ 
SQSSGSGSG LPLLVQRTI AKQIQMVRQ 
VGKGRYGEV WMGKWRGEK VAVKVFFTT 
EEASWFRET EIYQTVLMR HENILGFIA 
ADIKGTGSW TQLYLITDY HENGSLYDF 
LKCATLDTR ALLKLAYSA ACGLCHLHT 
EIYGTQGKP AIAHRDLKS KNILIKKNG 
SCCIADLGL AVKFNSDTN EVDVPLNTR 
VGTKRYMAP EVLDESLNK NHFQPYIMA 
DIYSFGLII WEMARRCIT GGIVEEYQL 
PYYNMVPSD PSYEDMREV VCVKRLRPI 
VSNRWNSDE CLRAVLKLM SECWAHNPA 
SRLTALRIK KTLAKMVES QDVKI

Binding hormones

  • BMP2
  • BMP4
  • GDF-6
    • The present findings indicate that BMPRII and ALK3 are receptors for GDF6. [1]

Anatomical structures with this receptor

  • skeleton_muscle

  • adrenal_cortex

    Induced phenotypes

    • Familial juvenile polyposis
      • Familial juvenile polyposis, an inherited hamartomatous polyposis syndrome with a high risk for colon cancer, has been associated with mutations in SMAD4 or BMPR1A. [2]
Reference