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Details for receptor: BMP receptor type IB

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EndoNet ID: ENR01027

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Synonyms

  • BMP receptor type IB
  • BMPR1B
  • bone morphogenetic protein receptor type IB
  • CDw293 antigen
  • activin receptor-like kinase 6
  • ALK-6
  • ALK6
  • BR1b
  • BMPR-IB
  • bone morphogenetic protein receptor, type IB

General information

Links to other resources

UniProt O00238
Ensembl ENST00000440890

Subunit information

Bone morphogenetic protein receptor type IB

Sequence 
KKEDGESTA PTPRPKVLR CKCHHHCPE 
DSVNNICST DGYCFTMIE EDDSGLPVV 
TSGCLGLEG SDFQCRDTP IPHQRRSIE 
CCTERNECN KDLHPTLPP LKNRDFVDG 
PIHHRALLI SVTVCSLLL VLIILFCYF 
RYKRQETRP RYSIGLEQD ETYIPPGES 
LRDLIEQSQ SSGSGSGLP LLVQRTIAK 
QIQMVKQIG KGRYGEVWM GKWRGEKVA 
VKVFFTTEE ASWFRETEI YQTVLMRHE 
NILGFIAAD IKGTGSWTQ LYLITDYHE 
NGSLYDYLK STTLDAKSM LKLAYSSVS 
GLCHLHTEI FSTQGKPAI AHRDLKSKN 
ILVKKNGTC CIADLGLAV KFISDTNEV 
DIPPNTRVG TKRYMPPEV LDESLNRNH 
FQSYIMADM YSFGLILWE VARRCVSGG 
IVEEYQLPY HDLVPSDPS YEDMREIVC 
IKKLRPSFP NRWSSDECL RQMGKLMTE 
CWAHNPASR LTALRVKKT LAKMSESQD 
IKL
UniProt O00238

Binding hormones

  • GDF5
    • BMPR1B is a receptor for growth/differentiation factor (GDF)-5. [1]

Anatomical structures with this receptor

  • granulosa_cell

    Influences

    • negative progesterone
      • BMP-4, a known ligand of Alk6, inhibits progesterone secretion by ovine granulosa cells in the absence of FSH. [2]
      • BMP-4 modulates progesterone by inhibiting the steroidogenic factor-1 (SF-1) transcriptional activity on steroidogenic gene promotors. In FSH-induced conditions, this mechanism might be reinforced by an inhibition of adenylate cyclase activity. [3]
    • positive estradiol
      • BMP-4 and BMP-7 enhance FSH-dependent estradiol production, suggesting that BMP factors regulate granulosa cell differentiation, particularty in delaying the luteinization process. [4]

  • adrenal_medulla

    Induced phenotypes

    • positive regulation of adrenal development
      • The introduction of a constitutively active type I BMP receptor in neural crest cells is sufficient to induce the development of adrenergic cells. [5]
      • Reduction of BMP-4-induced signalling is assiciated with smaller adrenal size in sheep. [2]
      • BMP is important for regulation of adrenal development, specially of adrenomedullary cell specification from neural crest. [6]

  • chondrocyte

    Induced phenotypes

    • brachydactyly type A2
      • BDA2 is caused by heterozygous missense mutations in BMPR1B. These mutations affect cartilage differentiation and bone formation in a dominant-negative way. [7]
    • acromesomelic chondrodysplasia with genital anomalies
      • Acromesomelic chondrodysplasias are a rare subgroup of hereditary skeletal disorders characterised by short stature, very short limbs, and hand/foot malformations due to a homozygous mutation in BMPR1B. This mutation is expected to result in a loss of function and is thus different from the heterozygous missense mutations in BMPR1B recently shown to cause brachydactyly type A2 through a dominant negative effect. [8]
Reference