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Details for receptor: TNFRSF18 isoform 1

EndoNet ID: ENR01036

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Synonyms

  • GITR
  • glucocorticoid-induced TNFR-related protein
  • AITR
  • activation-inducible TNFR family receptor
  • TNFRSF18 isoform 1
  • TNF receptor superfamily member 18
  • Tumor necrosis factor receptor superfamily member 18

General information

  • Isoform 2 is a secreted protein.

Links to other resources

UniProt Q9Y5U5
Ensembl ENST00000379268

Subunit information

Sequence
QRPTGGPGC GPGRLLLGT GTDARCCRV 
HTTRCCRDY PGEECCSEW DCMCVQPEF 
HCGDPCCTT CRHHPCPPG QGVQSQGKF 
SFGFQCIDC ASGTFSGGH EGHCKPWTD 
CTQFGFLTV FPGNKTHNA VCVPGSPPA 
EPLGWLTVV LLAVAACVL LLTSAQLGL 
HIWQLRSQC MWPRETQLL LEVPPSTED 
ARSCQFPEE ERGERSAEE KGRLGDLWV
UniProt Q9Y5U5-1

Binding hormones

  • TNFSF18

Anatomical structures with this receptor

  • lymph_node

    Induced phenotypes

    • leukocyte migration
      • TNFRSF18 and its ligand may be involved in activated T cell trafficking. [1]
    • The receptor is expressed in lymph node and peripheral blood leukocytes. [1]
  • spleen

    Induced phenotypes

    • negative regulation of lymphocyte apoptosis
      • TNFRSF18 and its ligand may modulate T lymphocyte survival in peripheral tissues and perhaps during interaction with the vascular endothelium. [2]
    • TNFRSF18 mRNA is expressed in peripheral blood leukocytes, bone marrow, spleen, thymus, lung and brain. [2]
Reference