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Details for receptor: TNFRSF12A

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EndoNet ID: ENR01038

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Synonyms

  • TNF-related weak inducer of apoptosis receptor
  • FN14
  • LOC51330
  • TNFRSF12A
  • Tweak-receptor
  • TweakR
  • FGF-inducible 14
  • type I transmembrane protein Fn14
  • Fibroblast growth factor-inducible immediate-early response protein 14
  • Tumor necrosis factor receptor superfamily member 12A

General information

  • The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas. [1]
  • TweakR/Fn14 is the smallest member of the TNF receptor (TNFR) superfamily described to date, and it appears to signal via recruitment of several different TNFR-associated factors. [2]
  • Soluble TweakR inhibits endothelial cell migration in vitro and corneal angiogenesis in vivo. [3]

Links to other resources

UniProt Q9NP84
Ensembl ENST00000341627

Subunit information

Sequence 
EQAPGTAPC SRGSSWSAD LDKCMDCAS 
CRARPHSDF CLGCAAAPP APFRLLWPI 
LGGALSLTF VLGLLSGFL VWRRCRRRE 
KFTTPIEET GGEGCPAVA LIQ
UniProt Q9NP84-1

Binding hormones

  • TNFSF12

Anatomical structures with this receptor

  • kidney

  • heart

    Induced phenotypes

    • positive regulation of smooth muscle proliferation
      • TNFSF12 induces proliferation of human aortic smooth muscle cells in vitro. [4]

  • smooth_muscle_cell

    Induced phenotypes

    • positive regulation of smooth muscle proliferation
      • TNFSF12 induces proliferation of human aortic smooth muscle cells in vitro and acts as a potent inducer of angiogenesis. [4]

  • smooth_muscle

    Induced phenotypes

    • positive regulation of smooth muscle proliferation
      • TNFSF12 induces proliferation of human aortic smooth muscle cells in vitro. [4]

  • vascularendothelial_cell

    Induced phenotypes

    • positive regulation of cell proliferation
      • TNFSF12 has a role in vasculature formation in vivo. [4]
      • TNFSF12 induces proliferation of endothelial cells in vitro and acts as a potent inducer of angiogenesis in a rat cornea pocket angiogenesis assay. [4]

  • continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

    Induced phenotypes

    • regulation of endothelial cell migration
      • TNFSF12 regulates an endothelial cell wound closure rate via its receptor TNFRSF12 who is important for endothelial cell migration. [3]
Reference