Status
Please wait ...

Details for receptor: TNFRSF17

EndoNet ID: ENR01040

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be:

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • BCMA
  • CD269 antigen
  • B-cell maturation protein
  • TNF receptor superfamily member 17
  • TNFRSF17
  • BCM
  • Tumor necrosis factor receptor superfamily member 17

General information

  • Promotes B-cell survival and plays a role in the regulation of humoral immunity. [1]
  • BCMA is a Member of the TNF receptor superfamily and is binding, even like TACI, the ligands APRIL and BAFF [2]

Links to other resources

UniProt Q02223
Ensembl ENST00000435355

Binding hormones

  • APRIL
  • BAFF

Anatomical structures with this receptor

  • B-lymphocyte

    Induced phenotypes

    • negative regulation of lymphocyte apoptosis
      • TNFRSF17 is a functional member of the TNFR superfamily. It is lacking a "death domain" and its overexpression activates NF-{kappa}B, p38, and JNK. Therefore, upon binding of its corresponding ligand, TNFRSF17 transduces signals for cell survival and proliferation. [3]
    • TNFRSF17 is a nonglycosylated integral membrane type I protein that is preferentially expressed in mature B lymphocytes. [4]
Reference