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Details for receptor: PLXND1

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  • General information
  • Subunits
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  • General information
  • Hormones
  • Anatomical structures
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EndoNet ID: ENR01041

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Synonyms

  • plexin D1
  • plexin-D1
  • PLXND1
  • KIAA0620
  • PLEXD1
  • Hs.105958
  • MGC75353
  • KIAA0620 protein

General information

  • PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development. [1]
  • Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. [2]
  • Plexin D1 expression is induced on tumor vasculature and tumor cells. [3]

Links to other resources

UniProt Q9Y4D7
Ensembl ENST00000393239

Subunit information

Plexin-D1, chain.

Sequence 
LEIQRRFPS PTPTNNFAL DGAAGTVYL 
AAVNRLYQL SGANLSLEA EAAVGPVPD 
SPLCHAPQL PQASCEHPR RLTDNYNKI 
LQLDPGQGL VVVCGSIYQ GFCQLRRRG 
NISAVAVRF PPAAPPAEP VTVFPSMLN 
VAANHPNAS TVGLVLPPA AGAGGSRLL 
VGATYTGYG SSFFPRNRS LEDHRFENT 
PEIAIRSLD TRGDLAKLF TFDLNPSDD 
NILKIKQGA KEQHKLGFV SAFLHPSDP 
PPGAQSYAY LALNSEARA GDKESQARS 
LLARICLPH GAGGDAKKL TESYIQLGL 
QCAGGAGRG DLYSRLVSV FPARERLFA 
VFERPQGSP AARAAPAAL CAFRFADVR 
AAIRAARTA CFVEPAPDV VAVLDSVVQ 
GTGPACERK LNIQLQPEQ LDCGAAHLQ 
HPLSILQPL KATPVFRAP GLTSVAVAS 
VNNYTAVFL GTVNGRLLK INLNESMQV 
VSRRVVTVA YGEPVHHVM QFDPADSVY 
LYLMTSHQM ARVKVAACN VHSTCGDCV 
GAADAYCGW CALETRCTL QQDCTNSSQ 
QHFWTSASE GPSRCPAMT VLPSEIDVR 
QEYPGMILQ ISGSLPSLS GMEMACDYG 
NNIRTVARV PGPAFGHQI AYCNLLPRD 
QFPPFPPNQ DHVTVEMSV RVNGRNIVK 
ANFTIYDCS RTAQVYPHT ACTSCLSAQ 
WPCFWCSQQ HSCVSNQSR CEASPNPTS 
PQDCPRTLL SPLAPVPTG GSQNILVPL 
ANTAFFQGA ALECSFGLE EIFEAVWVN 
ESVVRCDQV VLHTTRKSQ VFPLSLQLK 
GRPARFLDS PEPMTVMVY NCAMGSPDC 
SQCLGREDL GHLCMWSDG CRLRGPLQP 
MAGTCPAPE IRAIEPLSG PLDGGTLLT 
IRGRNLGRR LSDVAHGVW IGGVACEPL 
PDRYTVSEE IVCVTGPAP GPLSGVVTV 
NASKEGKSR DRFSYVLPL VHSLEPTMG 
PKAGGTRIT IHGNDLHVG SELQVLVND 
TDPCTELMR TDTSIACTM PEGALPAPV 
PVCVRFERR GCVHGNLTF WYMQNPVIT 
AISPRRSPV SGGRTITVA GERFHMVQN 
VSMAVHHIG REPTLCKVL NSTLITCPS 
PGALSNASA PVDFFINGR AYADEVAVA 
EELLDPEEA QRGSRFRLD YLPNPQFST 
AKREKWIKH HPGEPLTLV IHKEQDSLG 
LQSHEYRVK IGQVSCDIQ IVSDRIIHC 
SVNESLGAA VGQLPITIQ VGNFNQTIA 
TLQLGGSET AIIVSIVIC SVLLLLSVV 
ALFVFCTKS RRAERYWQK TLLQMEEME 
SQIREEIRK GFAELQTDM TDLTKELNR 
SQGIPFLEY KHFVTRTFF PKCSSLYEE 
RYVLPSQTL NSQGSSQAQ ETHPLLGEW 
KIPESCRPN MEEGISLFS SLLNNKHFL 
IVFVHALEQ QKDFAVRDR CSLASLLTI 
ALHGKLEYY TSIMKELLV DLIDASAAK 
NPKLMLRRT ESVVEKMLT NWMSICMYS 
CLRETVGEP FFLLLCAIK QQINKGSID 
AITGKARYT LNEEWLLRE NIEAKPRNL 
NVSFQGCGM DSLSVRAMD TDTLTQVKE 
KILEAFCKN VPYSQWPRA EDVDLEWFA 
SSTQSYILR DLDDTSVVE DGRKKLNTL 
AHYKIPEGA SLAMSLIDK KDNTLGRVK 
DLDTEKYFH LVLPTDELA EPKKSHRQS 
HRKKVLPEI YLTRLLSTK GTLQKFLDD 
LFKAILSIR EDKPPLAVK YFFDFLEEQ 
AEKRGISDP DTLHIWKTN SLPLRFWVN 
ILKNPQFVF DIDKTDHID ACLSVIAQA 
FIDACSISD LQLGKDSPT NKLLYAKEI 
PEYRKIVQR YYKQIQDMT PLSEQEMNA 
HLAEESRKY QNEFNTNVA MAEIYKYAK 
RYRPQIMAA LEANPTARR TQLQHKFEQ 
VVALMEDNI YECYSEA
UniProt Q9Y4D7

Binding hormones

  • semaphorin 3E
    • Sema3e uniquely signals through plexin D1 (PLXND1) independently of neuropilins. [4]

Anatomical structures with this receptor

  • heart

  • placenta

  • lung

  • skeleton_muscle

  • kidney

  • thymus

  • brain

    Induced phenotypes

    • CHARGE syndrome
      • Mutations in Sema3e are associated with CHARGE syndrome. [5]

  • colon

  • spleen

  • small_intestine

  • peripheral blood leukocytes

  • vascularendothelial_cell

  • continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

  • endocardium

  • intersomitic_vessel

  • pulmonary_vessels

  • aorta

  • testis

Reference