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Details for receptor: fas receptor

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  • Hormones
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EndoNet ID: ENR01050

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For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

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Synonyms

  • TNFRSF6
  • FAS
  • Apo-1
  • fas receptor
  • TNFRSF 6
  • CD95
  • Apo I
  • fas antigen
  • APT1

General information

  • Fas Receptor belongs to the TNF superfamily. By binding FasL to Fas Receptor, apoptosis will be induced in the Fas-bearing cells [1]
  • Hepatocytes, cholangiocytes, sinusoidal endothelial cells, stellate cells, and Kupffer cells all express Fas. [2]
  • A soluble Fas Receptor can inhibit the FasL-induced Celldeath, by acting as a a decoyreceptor, that binds FasL without any effect [1]
  • The upregulation of Fas in alcoholic hepatits might be a mechanism for ethanol-induced hepatocyte apoptosis in this disease. [3]

Links to other resources

UniProt P25445
Ensembl ENST00000371875

Subunit information

Sequence 
QVTDINSKG LELRKTVTT VETQNLEGL 
HHDGQFCHK PCPPGERKA RDCTVNGDE 
PDCVPCQEG KEYTDKAHF SSKCRRCRL 
CDEGHGLEV EINCTRTQN TKCRCKPNF 
FCNSTVCEH CDPCTKCEH GIIKECTLT 
SNTKCKEEG SRSNLGWLC LLLLPIPLI 
VWVKRKEVQ KTCRKHRKE NQGSHESPT 
LNPETVAIN LSDVDLSKY ITTIAGVMT 
LSQVKGFVR KNGVNEAKI DEIKNDNVQ 
DTAEQKVQL LRNWHQLHG KKEAYDTLI 
KDLKKANLC TLAEKIQTI ILKDITSDS 
ENSNFRNEI QSLV

Binding hormones

  • fas Ligand

Anatomical structures with this receptor

  • lipocyte_of_liver

    Induced phenotypes

    • negative regulation of apoptosis
      • CD95 ligand and other death receptor ligands act as mitogens in quiescent HSCs with simultaneous inhibition of proapoptotic signaling through an inactivating tyrosine nitration of the CD95 death receptor. [4]

  • hepatocyte

  • cholangiocyte

  • sinusoidal_endothelial_cell

  • Kupffer_cell_stellate_cell_of_liver

Reference