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Details for receptor: CysLTR1

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EndoNet ID: ENR01051

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Synonyms

  • CysLTR1
  • cysteinyl leukotriene D4 receptor
  • LTD4 receptor
  • HG55
  • HMTMF81
  • CYSLTR1
  • CYSLT1

General information

  • Rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4. [1]
  • Highest levels in spleen and peripheral blood leukocytes, lower expression in several tissues, such as lung (mostly in smooth muscle bundles and alveolar macrophages), placenta, small intestine, pancreas, colon and heart. [1]

Links to other resources

UniProt Q9Y271
Ensembl ENST00000373304

Subunit information

Sequence 
MDETGNLTV SSATCHDTI DDFRNQVYS 
TLYSMISVV GFFGNGFVL YVLIKTYHK 
KSAFQVYMI NLAVADLLC VCTLPLRVV 
YYVHKGIWL FGDFLCRLS TYALYVNLY 
CSIFFMTAM SFFRCIAIV FPVQNINLV 
TQKKARFVC VGIWIFVIL TSSPFLMAK 
PQKDEKNNT KCFEPPQDN QTKNHVLVL 
HYVSLFVGF IIPFVIIIV CYTMIILTL 
LKKSMKKNL SSHKKAIGM IMVVTAAFL 
VSFMPYHIQ RTIHLHFLH NETKPCDSV 
LRMQKSVVI TLSLAASNC CFDPLLYFF 
SGGNFRKRL STFRKHSLS SVTYVPRKK 
ASLPEKGEE ICKV

Binding hormones

  • LTC4
  • 12-epi-LTB4
  • LTB4
  • LTB4-d4
  • 12-keto-10,11,14,15-tetrahydro-LTB4
  • 12-oxo-LTB4
  • 20-carboxy-LTB4
  • LTB4 dimethyl amide
  • 20-hydroxy LTB4
  • LXB4
  • LXA4
  • LTE4
  • LTD4
  • 14,15-dehydro-LTB4
    • mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system [2]
    • mediating bronchoconstriction of individuals with and without asthma [2]
    • stimulation by LTD4, antagonist 14,15-dehydro-LTB4 [2]
  • 6-trans-LTB4
  • LTB4 ethanol amide

Anatomical structures with this receptor

  • spleen

  • lung

  • placenta

  • small_intestine

  • pancreas

  • colon

  • heart

  • peripheral blood leukocytes

Reference