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Details for receptor: LTB4-R2

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EndoNet ID: ENR01053

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Synonyms

  • BLT2
  • leukotriene B4 receptor BLT2
  • LTB4R2
  • LTB4-R2
  • seven transmembrane receptor BLTR2
  • leukotriene B4 receptor 2
  • LTB4 receptor JULF2
  • BLT2R
  • BLTR2

General information

  • G protein-coupled seven transmembrane domain receptor. [1]
  • Low-affinity receptor for leukotrienes, rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3. [2]
  • The two receptors for leukotriene B(4) differ in their affinity and specificity for LTB(4): BLT1 is a high-affinity receptor specific for LTB(4), whereas BLT2 is a low-affinity receptor that also binds other eicosanoids. [1]

Links to other resources

UniProt Q9NPC1
Ensembl ENST00000336557

Subunit information

Sequence 
MAPSHRASQ VGFCPTPER PLWRLPPTC 
RPRRMSVCY RPPGNETLL SWKTSRATG 
TAFLLLAAL LGLPGNGFV VWSLAGWRP 
ARGRPLAAT LVLHLALAD GAVLLLTPL 
FVAFLTRQA WPLGQAGCK AVYYVCALS 
MYASVLLTG LLSLQRCLA VTRPFLAPR 
LRSPALARR LLLAVWLAA LLLAVPAAV 
YRHLWRDRV CQLCHPSPV HAAAHLSLE 
TLTAFVLPF GLMLGCYSV TLARLRGAR 
WGSGRHGAR VGRLVSAIV LAFGLLWAP 
YHAVNLLQA VAALAPPEG ALAKLGGAG 
QAARAGTTA LAFFSSSVN PVLYVFTAG 
DLLPRAGPR FLTRLFEGS GEARGGGRS 
REGTMELRT TPQLKVVGQ GRGNGDPGG 
GMEKDGPEW DL

Binding hormones

  • LTB4
  • 12-oxo-LTB4
  • LTB4 ethanol amide
  • 14,15-dehydro-LTB4
    • low affinity receptor mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system [3]
  • LTB5
  • 6-trans-LTB4
  • 12-keto-10,11,14,15-tetrahydro-LTB4
  • LTB4-d4
  • 12-epi-LTB4
  • 20-carboxy-LTB4
  • LTB4 dimethyl amide
  • 20-hydroxy LTB4

Anatomical structures with this receptor

  • leukocyte

Reference