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Details for receptor: NPSR1

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  • Hormones
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EndoNet ID: ENR01055

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Synonyms

  • NPSR1
  • neuropeptide S receptor
  • G-protein coupled receptor 154
  • G-protein coupled receptor PGR14
  • GPR154
  • GPRA
  • PGR14

General information

  • G protein-coupled receptor 154 is an asthma susceptibility gene upregulated in the airways of asthma patients. [1]
  • Neuropeptide S and G protein-coupled receptor 154 modulate macrophage immune responses. [1]

Links to other resources

UniProt Q6W5P4
Ensembl ENST00000396095

Subunit information

Isoform A

Sequence 
MPANFTEGS FDSSGTGQT LDSSPVACT 
ETVTFTEVV EGKEWGSFY YSFKTEQLI 
TLWVLFVFT IVGNSVVLF STWRRKKKS 
RMTFFVTQL AITDSFTGL VNILTDINW 
RFTGDFTAP DLVCRVVRY LQVVLLYAS 
TYVLVSLSI DRYHAIVYP MKFLQGEKQ 
ARVLIVIAW SLSFLFSIP TLIIFGKRT 
LSNGEVQCW ALWPDDSYW TPYMTIVAF 
LVYFIPLTI ISIMYGIVI RTIWIKSKT 
YETVISNCS DGKLCSSYN RGLISKAKI 
KAIKYSIII ILAFICCWS PYFLFDILD 
NFNLLPDTQ ERFYASVII QNLPALNSA 
INPLIYCVF SSSISFPCR EQRSQDSRM 
TFRERTERH EMQILSKPE FI
UniProt Q6W5P4-1

Binding hormones

  • NPS

Anatomical structures with this receptor

  • amygdaloid_body

    Induced phenotypes

    • attenuation of anxiety behavior
      • NPS Attenuates Anxiety-like Behavior [2]
    • NPS receptor mRNA is widely distributed and most abundant in the amygdala, thalamus, hypothalamus, and cortex. [3]

  • thalamus

    Induced phenotypes

    • arousal
      • The arousal-promoting effect of NPS might be partially mediated by NPSRs expressed in thalamic midline nuclei, as this brain structure is known to act as a relay between arousal centers of the brainstem and the cortex. [4]

  • hypothalamus

  • cerebral_cortex

Reference