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Details for receptor: NPFF-R1

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EndoNet ID: ENR01056

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Synonyms

  • NPFF-R1
  • neuropeptide FF receptor 1
  • G-protein coupled receptor 147
  • NPFFR1
  • RFamide-related peptide receptor OT7T022
  • GPR147

General information

  • Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. [1]
  • Involved in pain processing. [2]

Links to other resources

UniProt Q9GZQ6
Ensembl ENST00000449957

Subunit information

Sequence 
MEGEPSQPP NSSWPLSQN GTNTEATPA 
TNLTFSSYY QHTSPVAAM FIVAYALIF 
LLCMVGNTL VCFIVLKNR HMHTVTNMF 
ILNLAVSDL LVGIFCMPT TLVDNLITG 
WPFDNATCK MSGLVQGMS VSASVFTLV 
AIAVERFRC IVHPFREKL TLRKALVTI 
AVIWALALL IMCPSAVTL TVTREEHHF 
MVDARNRSY PLYSCWEAW PEKGMRRVY 
TTVLFSHIY LAPLALIVV MYARIARKL 
CQAPGPAPG GEEAADPRA SRRRARVVH 
MLVMVALFF TLSWLPLWA LLLLIDYGQ 
LSAPQLHLV TVYAFPFAH WLAFFNSSA 
NPIIYGYFN ENFRRGFQA AFRARLCPR 
PSGSHKEAY SERPGGLLH RRVFVVVRP 
SDSGLPSES GPSSGAPRP GRLPLRNGR 
VAHHGLPRE GPGCSHLPL TIPAWDI

Binding hormones

  • NPFF
  • RFRP-1
  • RFRP-2
  • RFRP-3
  • NPAF

Anatomical structures with this receptor

  • hypothalamus

    Influences

    • negative GnRH-I
      • Thus, GnIH/RFRP may also inhibit gonadotropin synthesis and release by inhibiting GnRH neurons [3]
    • GnIH acts on the pituitary and on GnRH neurons in the hypothalamus via a novel G protein-coupled receptor (GPR147) [4]

  • pituitary_gland_of_diencephalon

    Influences

    • negative FSH
      • Thus, GnIH/RFRP may inhibit gonadotropin synthesis and release by direct actions on the pituitary gland. [3]
    • negative LH
      • Thus, GnIH/RFRP may inhibit gonadotropin synthesis and release by direct actions on the pituitary gland. [3]
    • GnIH acts on the pituitary and on GnRH neurons in the hypothalamus via a novel G protein-coupled receptor (GPR147) [4]
Reference