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Details for receptor: GPR7

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EndoNet ID: ENR01058

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Synonyms

  • NPBW-R1
  • neuropeptides B/W receptor type 1
  • G-protein coupled receptor 7
  • GPR7

General information

  • GPR7 and GPR8 are orphan G protein-coupled receptors that are highly similar to each other. These receptors are expressed predominantly in brain, suggesting roles in central nervous system function. [1]
  • Interacts specifically with a number of opioid ligands, Receptor for neuropeptides B and W. [2]
  • NPB and NPW are endogenous ligands on GPR7 and GPR8. [1]
  • Found in cerebellum and frontal cortex, detected at high levels in hipppocampus, amygdala and trachea, at moderate levels in fetal brain, pituitary gland and prostate. [2]

Links to other resources

UniProt P48145
Ensembl ENST00000331251

Subunit information

Sequence 
MDNASFSEP WPANASGPD PALSCSNAS 
TLAPLPAPL AVAVPVVYA VICAVGLAG 
NSAVLYVLL RAPRMKTVT NLFILNLAI 
ADELFTLVL PINIADFLL RQWPFGELM 
CKLIVAIDQ YNTFSSLYF LTVMSADRY 
LVVLATAES RRVAGRTYS AARAVSLAV 
WGIVTLVVL PFAVFARLD DEQGRRQCV 
LVFPQPEAF WWRASRLYT LVLGFAIPV 
STICVLYTT LLCRLHAMR LDSHAKALE 
RAKKRVTFL VVAILAVCL LCWTPYHLS 
TVVALTTDL PQTPLVIAI SYFITSLTY 
ANSCLNPFL YAFLDASFR RNLRQLITC 
RAAA

Binding hormones

  • NPB29
  • NPW30
  • NPW23
    • NPW23 activates GPR7(NPBW-R1) and GPR8(NPBW-R2) more efficiently than NPW30. [2]
  • NPB23

Anatomical structures with this receptor

  • cerebellum

  • frontal_lobe

  • hippocampus

  • amygdaloid_body

  • trachea

  • adenohypophysis

Reference