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Details for receptor: GPR8

EndoNet ID: ENR01059

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  • NPBW-R2
  • NPBWR2
  • neuropeptides B/W receptor type 2
  • GPR8

General information

  • GPR7 and GPR8 are orphan G protein-coupled receptors that are highly similar to each other. These receptors are expressed predominantly in brain, suggesting roles in central nervous system function. [1]
  • NPB and NPW are endogenous ligands on GPR7 and GPR8. [1]

Links to other resources

UniProt P48146
Ensembl ENST00000369768

Binding hormones

  • NPB29
  • NPW23
    • NPW23 activates GPR7(NPBW-R1) and GPR8(NPBW-R2) more efficiently than NPW30. [2]
  • NPW30
  • NPB23

Anatomical structures with this receptor