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Details for receptor: renin receptor

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EndoNet ID: ENR01062

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Synonyms

  • renin receptor
  • renin/prorenin receptor
  • ATP6AP2
  • ATP6IP2

General information

  • High levels found in the heart, brain, placenta, and lower levels in the kidney and liver. [1]

Links to other resources

UniProt O75787
Ensembl ENST00000447485

Subunit information

Sequence 
NEFSILKSP GSVVFRNGN WPIPGERIP 
DVAALSMGF SVKEDLSWP GLAVGNLFH 
RPRATVMVM VKGVNKLAL PPGSVISYP 
LENAVPFSL DSVANSIHS LFSEETPVV 
LQLAPSEER VYMVGKANS VFEDLSVTL 
RQLRNRLFQ ENSVLSSLP LNSLSRNNE 
VDLLFLSEL QVLHDISSL LSRHKHLAK 
DHSPDLYSL ELAGLDEIG KRYGEDSEQ 
FRDASKILV DALQKFADD MYSLYGGNA 
VVELVTVKS FDTSLIRKT RTILEAKQA 
KNPASPYNL AYKYNFEYS VVFNMVLWI 
MIALALAVI ITSYNIWNM DPGYDSIIY 
RMTNQKIRM D

Binding hormones

  • renin
    • Increases the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I. [2]

Anatomical structures with this receptor

  • heart

    • High levels found in the heart, brain, placenta, and lower levels in the kidney and liver. [1]

  • brain

    • High levels found in the heart, brain, placenta, and lower levels in the kidney and liver. [1]

  • placenta

    • High levels found in the heart, brain, placenta, and lower levels in the kidney and liver. [1]

  • kidney

    Influences

    • positive renin
      • The (pro)renin receptor binds both renin and prorenin and is reported to increase the catalytic efficiency of renin and activate prorenin. [1]
      • Thus, binding of renin and prorenin not only stimulates the (pro)renin receptor but also increases angiotensin II formation, leading to angiotensin II type 1 receptor stimulation. [3]
    • positive angiotensin II
      • Renin binding to the renin receptor in the kidney secretes angiotensin 1 which is converted to angiotensin 2 [4]
    • High levels found in the heart, brain, placenta, and lower levels in the kidney and liver. [1]
Reference