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Details for receptor: hepatocyte growth factor receptor

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EndoNet ID: ENR01069

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Synonyms

  • hepatocyte growth factor receptor
  • HGF receptor
  • scatter factor receptor
  • SF receptor
  • HGF/SF receptor
  • met proto-oncogene tyrosine kinase
  • c-Met
  • MET
  • met tyrosine kinase
  • HGFR

General information

  • Binds PLXNB1, RANBP9, and GRB2. [1]
  • The semaphorin 4D receptor controls invasive growth by coupling with Met. [2]
  • The MET oncogene drives a genetic programme linking cancer to haemostasis.
  • The malaria parasite exploits MET not as a primary binding site, but as a mediator of signals that make the host cell susceptible to infection. [3]

Links to other resources

UniProt P08581
Ensembl ENST00000456159

Subunit information

Hepatocyte growth factor receptor, isoform 1.

Sequence 
ECKEALAKS EMNVNMKYQ LPNFTAETP 
IQNVILHEH HIFLGATNY IYVLNEEDL 
QKVAEYKTG PVLEHPDCF PCQDCSSKA 
NLSGGVWKD NINMALVVD TYYDDQLIS 
CGSVNRGTC QRHVFPHNH TADIQSEVH 
CIFSPQIEE PSQCPDCVV SALGAKVLS 
SVKDRFINF FVGNTINSS YFPDHPLHS 
ISVRRLKET KDGFMFLTD QSYIDVLPE 
FRDSYPIKY VHAFESNNF IYFLTVQRE 
TLDAQTFHT RIIRFCSIN SGLHSYMEM 
PLECILTEK RKKRSTKKE VFNILQAAY 
VSKPGAQLA RQIGASLND DILFGVFAQ 
SKPDSAEPM DRSAMCAFP IKYVNDFFN 
KIVNKNNVR CLQHFYGPN HEHCFNRTL 
LRNSSGCEA RRDEYRTEF TTALQRVDL 
FMGQFSEVL LTSISTFIK GDLTIANLG 
TSEGRFMQV VVSRSGPST PHVNFLLDS 
HPVSPEVIV EHTLNQNGY TLVITGKKI 
TKIPLNGLG CRHFQSCSQ CLSAPPFVQ 
CGWCHDKCV RSEECLSGT WTQQICLPA 
IYKVFPNSA PLEGGTRLT ICGWDFGFR 
RNNKFDLKK TRVLLGNES CTLTLSEST 
MNTLKCTVG PAMNKHFNM SIIISNGHG 
TTQYSTFSY VDPVITSIS PKYGPMAGG 
TLLTLTGNY LNSGNSRHI SIGGKTCTL 
KSVSNSILE CYTPAQTIS TEFAVKLKI 
DLANRETSI FSYREDPIV YEIHPTKSF 
ISGGSTITG VGKNLNSVS VPRMVINVH 
EAGRNFTVA CQHRSNSEI ICCTTPSLQ 
QLNLQLPLK TKAFFMLDG ILSKYFDLI 
YVHNPVFKP FEKPVMISM GNENVLEIK 
GNDIDPEAV KGEVLKVGN KSCENIHLH 
SEAVLCTVP NDLLKLNSE LNIEWKQAI 
SSTVLGKVI VQPDQNFTG LIAGVVSIS 
TALLLLLGF FLWLKKRKQ IKDLGSELV 
RYDARVHTP HLDRLVSAR SVSPTTEMV 
SNESVDYRA TFPEDQFPN SSQNGSCRQ 
VQYPLTDMS PILTSGDSD ISSPLLQNT 
VHIDLSALN PELVQAVQH VVIGPSSLI 
VHFNEVIGR GHFGCVYHG TLLDNDGKK 
IHCAVKSLN RITDIGEVS QFLTEGIIM 
KDFSHPNVL SLLGICLRS EGSPLVVLP 
YMKHGDLRN FIRNETHNP TVKDLIGFG 
LQVAKGMKY LASKKFVHR DLAARNCML 
DEKFTVKVA DFGLARDMY DKEYYSVHN 
KTGAKLPVK WMALESLQT QKFTTKSDV 
WSFGVVLWE LMTRGAPPY PDVNTFDIT 
VYLLQGRRL LQPEYCPDP LYEVMLKCW 
HPKAEMRPS FSELVSRIS AIFSTFIGE 
HYVHVNATY VNVKCVAPY PSLLSSEDN 
ADDEVDTRP ASFWETS
UniProt P08581

Hepatocyte growth factor receptor, isoform 2.

Sequence 
ECKEALAKS EMNVNMKYQ LPNFTAETP 
IQNVILHEH HIFLGATNY IYVLNEEDL 
QKVAEYKTG PVLEHPDCF PCQDCSSKA 
NLSGGVWKD NINMALVVD TYYDDQLIS 
CGSVNRGTC QRHVFPHNH TADIQSEVH 
CIFSPQIEE PSQCPDCVV SALGAKVLS 
SVKDRFINF FVGNTINSS YFPDHPLHS 
ISVRRLKET KDGFMFLTD QSYIDVLPE 
FRDSYPIKY VHAFESNNF IYFLTVQRE 
TLDAQTFHT RIIRFCSIN SGLHSYMEM 
PLECILTEK RKKRSTKKE VFNILQAAY 
VSKPGAQLA RQIGASLND DILFGVFAQ 
SKPDSAEPM DRSAMCAFP IKYVNDFFN 
KIVNKNNVR CLQHFYGPN HEHCFNRTL 
LRNSSGCEA RRDEYRTEF TTALQRVDL 
FMGQFSEVL LTSISTFIK GDLTIANLG 
TSEGRFMQV VVSRSGPST PHVNFLLDS 
HPVSPEVIV EHTLNQNGY TLVITGKKI 
TKIPLNGLG CRHFQSCSQ CLSAPPFVQ 
CGWCHDKCV RSEECLSGT WTQQICLPA 
IYKVFPNSA PLEGGTRLT ICGWDFGFR 
RNNKFDLKK TRVLLGNES CTLTLSEST 
MNTLKCTVG PAMNKHFNM SIIISNGHG 
TTQYSTFSY VDPVITSIS PKYGPMAGG 
TLLTLTGNY LNSGNSRHI SIGGKTCTL 
KSVSNSILE CYTPAQTIS TEFAVKLKI 
DLANRETSI FSYREDPIV YEIHPTKSF 
ISTWWKEPL NIVSFLFCF ASGGSTITG 
VGKNLNSVS VPRMVINVH EAGRNFTVA 
CQHRSNSEI ICCTTPSLQ QLNLQLPLK 
TKAFFMLDG ILSKYFDLI YVHNPVFKP 
FEKPVMISM GNENVLEIK GNDIDPEAV 
KGEVLKVGN KSCENIHLH SEAVLCTVP 
NDLLKLNSE LNIEWKQAI SSTVLGKVI 
VQPDQNFTG LIAGVVSIS TALLLLLGF 
FLWLKKRKQ IKDLGSELV RYDARVHTP 
HLDRLVSAR SVSPTTEMV SNESVDYRA 
TFPEDQFPN SSQNGSCRQ VQYPLTDMS 
PILTSGDSD ISSPLLQNT VHIDLSALN 
PELVQAVQH VVIGPSSLI VHFNEVIGR 
GHFGCVYHG TLLDNDGKK IHCAVKSLN 
RITDIGEVS QFLTEGIIM KDFSHPNVL 
SLLGICLRS EGSPLVVLP YMKHGDLRN 
FIRNETHNP TVKDLIGFG LQVAKGMKY 
LASKKFVHR DLAARNCML DEKFTVKVA 
DFGLARDMY DKEYYSVHN KTGAKLPVK 
WMALESLQT QKFTTKSDV WSFGVVLWE 
LMTRGAPPY PDVNTFDIT VYLLQGRRL 
LQPEYCPDP LYEVMLKCW HPKAEMRPS 
FSELVSRIS AIFSTFIGE HYVHVNATY 
VNVKCVAPY PSLLSSEDN ADDEVDTRP 
ASFWETS
UniProt P08581-2

Binding hormones

  • HGF
  • SEMA4D
    • Met, a scatter factor/hepatocyte growth factor receptor with intrinsic kinase activity, is required to transduce CD100/Sema4D signals promoting epithelial cell invasive growth; this receptor forms a receptor complex with plexin-B1. [2]

Anatomical structures with this receptor

  • digestive_system

  • kidney

  • stomach

  • epithelial_cell

    Induced phenotypes

    • branching morphogenesis
      • CD100/Sema4D, as well as scatter factor, triggers invasive growth - this phenomenon is a complex program including branching morphogenesis, in which cells acquire polarity and form tubules arranged like branches of a tree. [2]
    • positive regulation of cell growth
      • CD100/Sema4D, as well as scatter factor, triggers invasive growth - this phenomenon is a complex program including cell-cell-dissociation and anchorage-independent growth. [2]

  • thyroid_gland

  • colon

  • vascularendothelial_cell

  • continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

    Induced phenotypes

    • positive regulation of cell growth
      • In epithelial cells, plexin-B1 forms a functional receptor complex with Met (the scatter factor-1/hepatocyte growth factor receptor). [2]
      • Activation of Met through plexin-B1 requires the extracellular domains of both receptors. The phosphorylation of the plexin-B1/Met complex induced by CD100/Sema4D, which is significantly increased when both CD100/Sema4D and the Met ligand scatter factor-1 are present, is crucial for epithelial cell invasive growth. [4]

  • umbilical_vein_endothelial_cells

  • hepatocyte

  • small_intestine

  • placenta

Reference