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Details for receptor: basigin

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EndoNet ID: ENR01070

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Synonyms

  • basigin
  • leukocyte activation antigen M6
  • collagenase stimulatory factor
  • extracellular matrix metalloproteinase inducer
  • EMMPRIN
  • 5F7
  • tumor cell-derived collagenase stimulatory factor
  • TCSF
  • OK blood group antigen
  • CD147 antigen
  • BSG

General information

  • CD147 is a signaling receptor for extracellular cyclophilins A and B. [1]
  • EMMPRIN is present on the surface of tumor cells and stimulates nearby fibroblasts to synthesize matrix metalloproteinases. [2]
  • CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production. [3]
  • CD147 facilitates HIV-1 infection by interacting with virus-associated cyclophilin A. [4]
  • Transmembrane glycoprotein member of the immunoglobulin superfamily. [5]

Links to other resources

UniProt P35613
Ensembl ENST00000396012

Subunit information

Basigin isoform 1 (long basigin, basigin-2).

Sequence 
AAGFVQAPL SQQRWVGGS VELHCEAVG 
SPVPEIQWW FEGQGPNDT CSQLWDGAR 
LDRVHIHAT YHQHAASTI SIDTLVEED 
TGTYECRAS NDPDRNHLT RAPRVKWVR 
AQAVVLVLE PGTVFTTVE DLGSKILLT 
CSLNDSATE VTGHRWLKG GVVLKEDAL 
PGQKTEFKV DSDDQWGEY SCVFLPEPM 
GTANIQLHG PPRVKAVKS SEHINEGET 
AMLVCKSES VPPVTDWAW YKITDSEDK 
ALMNGSESR FFVSSSQGR SELHIENLN 
MEADPGQYR CNGTSSKGS DQAIITLRV 
RSHLAALWP FLGIVAEVL VLVTIIFIY 
EKRRKPEDV LDDDDAGSA PLKSSGQHQ 
NDKGKNVRQ RNSS
UniProt P35613

basigin isoform 3

Sequence 
MGTANIQLH GPPRVKAVK SSEHINEGE 
TAMLVCKSE SVPPVTDWA WYKITDSED 
KALMNGSES RFFVSSSQG RSELHIENL 
NMEADPGQY RCNGTSSKG SDQAIITLR 
VRSHLAALW PFLGIVAEV LVLVTIIFI 
YEKRRKPED VLDDDDAGS APLKSSGQH 
QNDKGKNVR QRNSS

basigin isoform 4

Sequence 
MKQSDASPQ ERVDSDDQW GEYSCVFLP 
EPMGTANIQ LHGPPRVKA VKSSEHINE 
GETAMLVCK SESVPPVTD WAWYKITDS 
EDKALMNGS ESRFFVSSS QGRSELHIE 
NLNMEADPG QYRCNGTSS KGSDQAIIT 
LRVRSHLAA LWPFLGIVA EVLVLVTII 
FIYEKRRKP EDVLDDDDA GSAPLKSSG 
QHQNDKGKN VRQRNSS

Basigin isoform 2.

Sequence 
AAGTVFTTV EDLGSKILL TCSLNDSAT 
EVTGHRWLK GGVVLKEDA LPGQKTEFK 
VDSDDQWGE YSCVFLPEP MGTANIQLH 
GPPRVKAVK SSEHINEGE TAMLVCKSE 
SVPPVTDWA WYKITDSED KALMNGSES 
RFFVSSSQG RSELHIENL NMEADPGQY 
RCNGTSSKG SDQAIITLR VRSHLAALW 
PFLGIVAEV LVLVTIIFI YEKRRKPED 
VLDDDDAGS APLKSSGQH QNDKGKNVR 
QRNSS
UniProt P35613-2

Binding hormones

    Anatomical structures with this receptor

    • retina

    • eye

    • brain

      Influences

      • positive MMP-3
        • CD147/Basigin induces matrix metalloproteinase expression in neighbouring fibroblasts, leading to tumor cell invasion [6]

    • blood_vessel

      Induced phenotypes

      • regulation of angiogenesis
        • Basigning regulates angiogenesis by increasing protease production ass well as by upregulation of hypoxia-inducible factor-2alpha, VEGFR2, and the soluble forms of VEGF. [7]

    • peripheral blood lymphocytes

    • macrophage

    • cell_of_endometrium_of_uterus

    • mast_cell

    Reference