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Details for receptor: bile acid receptor

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EndoNet ID: ENR01078

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Synonyms

  • farnesoid X-activated receptor
  • retinoid X receptor-interacting protein 14
  • RXR-interacting protein 14
  • bile acid receptor
  • NR1H4
  • FXR
  • farnesol receptor HRR-1

General information

Links to other resources

UniProt Q96RI1
Ensembl ENST00000392986

Subunit information

bile acid receptor

  • Heterodimer of NR1H4 and RXR.
Sequence 
MVMQFQGLE NPIQISPHC SCTPSGFFM 
EMMSMKPAK GVLTEQVAG PLGQNLEVE 
PYSQYSNVQ FPQVQPQIS SSSYYSNLG 
FYPQQPEEW YSPGIYELR RMPAETLYQ 
GETEVAEMP VTKKPRMGA SAGRIKGDE 
LCVVCGDRA SGYHYNALT CEGCKGFFR 
RSITKNAVY KCKNGGNCV MDMYMRRKC 
QECRLRKCK EMGMLAECM YTGLLTEIQ 
CKSKRLRKN VKQHADQTV NEDSEGRDL 
RQVTSTTKS CREKTELTP DQQTLLHFI 
MDSYNKQRM PQEITNKIL KEEFSAEEN 
FLILTEMAT NHVQVLVEF TKKLPGFQT 
LDHEDQIAL LKGSAVEAM FLRSAEIFN 
KKLPSGHSD LLEERIRNS GISDEYITP 
MFSFYKSIG ELKMTQEEY ALLTAIVIL 
SPDRQYIKD REAVEKLQE PLLDVLQKL 
CKIHQPENP QHFACLLGR LTELRTFNH 
HHAEMLMSW RVNDHKFTP LLCEIWDVQ
UniProt Q96RI1-3

Binding hormones

    Anatomical structures with this receptor

    • hepatocyte

      Influences

      • positive FGF-19
        • FXR induces expression of FGF-19 in primary cultures of human hepatocytes. [1]
      • positive APOA5
        • Bile acids induce human apoAV promoter activity via FXR. [2]
      • positive fetuin-B
        • FXR agonists induce fetuin-B expression in human primary hepatocytes. [3]
    Reference