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Details for receptor: TACI

EndoNet ID: ENR01082

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  • TACI
  • TNF receptor superfamily member 13B
  • transmembrane activator and CAML interactor
  • CD267 antigen

General information

  • TACI can bind to both APRIL and BAFF and can so stimulate the activation of AP-1, NF-kappaB and mediates calcineurzn dependent activation of NF-AT. [1]
  • TACI is a member of the TNF receptor Superfamily. It is expressed in the small intestine, spleen, thymus, peripheral blood leukocytes, activated T-cells and resting B-cells. [1]
  • Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. [2]

Links to other resources

UniProt O14836
Ensembl ENST00000437538

Binding hormones

  • BAFF

Anatomical structures with this receptor

  • small_intestine

  • thymus

  • spleen