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Details for receptor: LTBR

EndoNet ID: ENR01086

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Synonyms

  • LTBR
  • TNF receptor superfamily member 3
  • lymphotoxin-beta receptor
  • TNF receptor 2-related protein
  • tumor necrosis factor C receptor
  • TNFCR
  • TNFRSF3
  • CD18
  • LT-beta-R
  • LTA
  • lymphotoxin B receptor
  • lymphotoxin beta receptor
  • TNFR2-RP
  • TNFR-RP
  • TNFCR

General information

  • The Lymphotoxin-β Receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells. [1]

Links to other resources

UniProt P36941
Ensembl ENST00000228918

Binding hormones

  • TNF-beta
    • The membranebound heterotrimer of one LTA (TNF-beta) and two LTB (TNF-C) subunits binds to the lymphotoxin receptor. [2]
  • TNF-C
    • The membranebound heterotrimer of one LTA (TNF-beta) and two LTB (TNF-C) subunits binds to the lymphotoxin receptor. [2]
  • LIGHT
    • LIGHT is a tumor necrosis factor (TNF) ligand superfamily member, which binds to the lymphotoxin-β receptor (LTβR) [1]

Anatomical structures with this receptor

  • stromal_cell_

    Induced phenotypes

    • formation of secondary lymphoid tissue
      • At least two cell types are necessary for secondary lymphoid organ formation: an embryonic stroma organizer cell expressing the LTβR and the LTαβ expressing “inducer” cell (a CD4+CD3- IL7Rα+ mononuclear cell). [3]
    • LTβR expression is largely restricted to stromal and myeloid cells. [4]
  • blood_myeloid_cell

    • LTβR expression is largely restricted to stromal and myeloid cells. [4]
Reference