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Details for receptor: GPR54

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EndoNet ID: ENR01089

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Synonyms

  • GPR54
  • KiSS-1 receptor
  • KiSS-1R
  • kisspeptin receptor
  • metastin receptor
  • G-protein coupled receptor 54
  • hypogonadotropin-1
  • hOT7T175
  • KISS1R
  • AXOR12

General information

  • In the cerebellum AXOR12 was strikingly localized to the surface of the Purkinje cells and their apical dendrites. [1]
  • Coupled to Galphaq subunits. [2]
  • Patients with loss-of-function mutations in GPR54 have idiopathic hypogonadotropic hypogonadism. [3]
  • Stimulates phospholipase C and arachidonic acid release.

Links to other resources

UniProt Q969F8
Ensembl ENST00000234371

Subunit information

KiSS-1 receptor

Sequence 
MHTVATSGP NASWGAPAN ASGCPGCGA 
NASDGPVPS PRAVDAWLV PLFFAALML 
LGLVGNSLV IYVICRHKP MRTVTNFYI 
ANLAATDVT FLLCCVPFT ALLYPLPGW 
VLGDFMCKF VNYIQQVSV QATCATLTA 
MSVDRWYVT VFPLRALHR RTPRLALAV 
SLSIWVGSA AVSAPVLAL HRLSPGPRA 
YCSEAFPSR ALERAFALY NLLALYLLP 
LLATCACYA AMLRHLGRV AVRPAPADS 
ALQGQVLAE RAGAVRAKV SRLVAAVVL 
LFAACWGPI QLFLVLQAL GPAGSWHPR 
SYAAYALKT WAHCMSYSN SALNPLLYA 
FLGSHFRQA FRRVCPCAP RRPRRPRRP 
GPSDPAAPH AELHRLGSH PAPARAQKP 
GSSGLAARG LCVLGEDNA PL
UniProt Q969F8

Binding hormones

  • metastin
  • kisspeptin-10

Anatomical structures with this receptor

  • gonadotropin_releasing_hormone_neuron

    Influences

    • positive GnRH-I
      • Kisspeptins stimulate the secretion of gonadotropins from the pituitary by stimulating the release of GnRH from the forebrain after the activation of GPR54, which is expressed by GnRH neurons. [4]

  • cerebellum

Reference