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Details for receptor: CMKLR1

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EndoNet ID: ENR01090

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Synonyms

  • CMKLR1
  • ChemR23
  • chemerinR
  • chemokine-like receptor 1
  • orphan G-protein coupled receptor, Dez
  • chemokine receptor-like 1

General information

  • Present on plasmacytoid dendritic cells and macrophages. [1]
  • Activation of chemerin receptor results in intracellular calcium release, inhibition of cAMP accumulation, and phosphorylation of p42-p44 MAP kinases, through the Gi class of heterotrimeric G proteins. [2]

Links to other resources

UniProt Q99788
Ensembl ENST00000436420

Subunit information

Chemokine receptor-like 1.

Sequence 
MRMEDEDYN TSISYGDEY PDYLDSIVV 
LEDLSPLEA RVTRIFLVV VYSIVCFLG 
ILGNGLVII IATFKMKKT VNMVWFLNL 
AVADFLFNV FLPIHITYA AMDYHWVFG 
TAMCKISNF LLIHNMFTS VFLLTIISS 
DRCISVLLP VWSQNHRSV RLAYMACMV 
IWVLAFFLS SPSLVFRDT ANLHGKISC 
FNNFSLSTP GSSSWPTHS QMDPVGYSR 
HMVVTVTRF LCGFLVPVL IITACYLTI 
VCKLQRNRL AKTKKPFKI IVTIIITFF 
LCWCPYHTL NLLELHHTA MPGSVFSLG 
LPLATALAI ANSCMNPIL YVFMGQDFK 
KFKVALFSR LVNALSEDT GHSSYPSHR 
SFTKMSSMN ERTSMNERE TGML
UniProt Q99788

Binding hormones

  • resolvin E1
    • Receptor for the omega-3 fatty acid derived molecule resolvin E1. [3]
  • chemerin
    • Here we present the characterization of chemerin, a novel chemoattractant protein, which acts through ChemR23 (CMKLR1). [2]

Anatomical structures with this receptor

  • macrophage

    Induced phenotypes

    • chemotaxis of macrophages
      • Human recombinant chemerin promoted in vitro migration of macrophages was observed. [2]
    • We have previously described ChemR23 as a human orphan G protein–coupled receptor expressed in macrophages and immature DCs [2]

  • dendritic_cell_in_lymphoid_tissues

    Induced phenotypes

    • dendritic cell chemotaxis
      • Human recombinant chemerin promoted in vitro migration of immature DCs whereas no chemotaxis of mature DCs was observed [2]
    • We have previously described ChemR23 as a human orphan G protein–coupled receptor expressed in macrophages and immature DCs [2]

  • endothelial_cell

    Induced phenotypes

    • angiogenesis
      • Our data provide the first evidence of chemerin-induced endothelial angiogenesis. [4]
    • We have demonstrated the novel presence of ChemR23 in human ECs [4]

  • chondrocyte

    Influences

    • positive interleukin 6
      • The results show an increased concentration of IL-6 as a result of chemerin stimulation in comparison to unstimulated control cells [5]
    • positive IL-8
      • The results show an increased concentration of IL-8 as a result of chemerin stimulation in comparison to unstimulated control cells [6]
    • Chondrocytes in both native cartilage and cell culture express the chemokine receptor ChemR23 [6]
Reference