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Details for receptor: IL-4R type l

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EndoNet ID: ENR01101

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Synonyms

  • IL4R type l
  • interleukin 4 receptor type 1
  • IL-4Ralpha:gamma-c
  • IL-4R type l

General information

  • In immune cells, ILR4alpha and common gamma chain creates a ILR4 type I receptor. [1]

Links to other resources

Subunit information

interleukin-4 receptor alpha chain (1 times)

Sequence 
MKVLQEPTC VSDYMSIST CEWKMNGPT 
NCSTELRLL YQLVFLLSE AHTCIPENN 
GGAGCVCHL LMDDVVSAD NYTLDLWAG 
QQLLWKGSF KPSEHVKPR APGNLTVHT 
NVSDTLLLT WSNPYPPDN YLYNHLTYA 
VNIWSENDP ADFRIYNVT YLEPSLRIA 
ASTLKSGIS YRARVRAWA QCYNTTWSE 
WSPSTKWHN SYREPFEQH LLLGVSVSC 
IVILAVCLL CYVSITKIK KEWWDQIPN 
PARSRLVAI IIQDAQGSQ WEKRSRGQE 
PAKCPHWKN CLTKLLPCF LEHNMKRDE 
DPHKAAKEM PFQGSGKSA WCPVEISKT 
VLWPESISV VRCVELFEA PVECEEEEE 
VEEEKGSFC ASPESSRDD FQEGREGIV 
ARLTESLFL DLLGEENGG FCQQDMGES 
CLLPPSGST SAHMPWDEF PSAGPKEAP 
PWGKEQPLH LEPSPPASP TQSPDNLTC 
TETPLVIAG NPAYRSFSN SLSQSPCPR 
ELGPDPLLA RHLEEVEPE MPCVPQLSE 
PTTVPQPEP ETWEQILRR NVLQHGAAA 
APVSAPTSG YQEFVHAVE QGGTQASAV 
VGLGPPGEA GYKAFSSLL ASSAVSPEK 
CGFGASSGE EGYKPFQDL IPGCPGDPA 
PVPVPLFTF GLDREPPRS PQSSHLPSS 
SPEHLGLEP GEKVEDMPK PPLPQEQAT 
DPLVDSLGS GIVYSALTC HLCGHLKQC 
HGQEDGGQT PVMASPCCG CCCGDRSSP 
PTTPLRAPD PSPGGVPLE ASLCPASLA 
PSGISEKSK SSSSFHPAP GNAQSSSQT 
PKIVNFVSV GPTYMRVS
UniProt P24394-1

cytokine receptor common gamma chain (1 times)

Sequence 
LNTTILTPN GNEDTTADF FLTTMPTDS 
LSVSTLPLP EVQCFVFNV EYMNCTWNS 
SSEPQPTNL TLHYWYKNS DNDKVQKCS 
HYLFSEEIT SGCQLQKKE IHLYQTFVV 
QLQDPREPR RQATQMLKL QNLVIPWAP 
ENLTLHKLS ESQLELNWN NRFLNHCLE 
HLVQYRTDW DHSWTEQSV DYRHKFSLP 
SVDGQKRYT FRVRSRFNP LCGSAQHWS 
EWSHPIHWG SNTSKENPF LFALEAVVI 
SVGSMGLII SLLCVYFWL ERTMPRIPT 
LKNLEDLVT EYHGNFSAW SGVSKGLAE 
SLQPDYSER LCLVSEIPP KGGALGEGP 
GASPCNQHS PYWAPPCYT LKPET
UniProt P31785

Binding hormones

  • IL-4

Anatomical structures with this receptor

  • monocyte

    Influences

    • negative IL-12B
      • IL-4 decreased p40 production 8- to 30-fold. [2]
    • negative IL-12
      • The effect of 300 U/ml IL-4 on p70 production varied between donors, resulting in either no effect or a 2-fold decrease in the p70 production. [2]
    • negative IL-10
      • IL-4 also inhibited IL-10 and IL-6 production in all donors. [2]
    • negative interleukin 6
      • IL-4 also inhibited IL-I0 and IL-6 production in all donors. [3]

  • B-lymphocyte

    Influences

    • positive IgE
Reference