Please wait ...

Details for receptor: NPR2

EndoNet ID: ENR01109

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be:

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like
If the search pattern is unambigious the user is directed to the corresponding detail page.


  • NPR2
  • natriuretic peptide receptor 2
  • ANP-B
  • atrial natriuretic peptide receptor B
  • atrial natriuretic peptide B-type receptor
  • NPR-B
  • GC-B
  • guanylate cyclase B

General information

  • NPR-B represent one of the five transmembrane guanylyl cyclases found in humans. [1]

Links to other resources

UniProt P20594
Ensembl ENST00000455603

Binding hormones

  • C-type natriuretic peptide
    • The rank order of activation of NPR-B (NPR-2) by natriuretic peptides is CNP ≫ ANP ≥ BNP [1]

Anatomical structures with this receptor

  • chondrocyte

    Induced phenotypes

    • long bone growth
      • CNP-dependent long bone growth requires CNP binding and activation of NPR-2, cGMP binding, and activation of PKGII and PKGII-dependent increases in the proliferation of hypertrophic chondrocytes. [2]
    • NPR-B is expressed in proliferative and prehypertrophic chondrocytes. [2]
  • smooth_muscle_cell

    Induced phenotypes

    • vascular relaxation
      • NPR-B is present in aortic vascular smooth muscle and mediates CNP relaxation of precontracted rat aorta. [1]
    • NPR-B is present in aortic vascular smooth muscle . [1]