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Details for receptor: NPR2

EndoNet ID: ENR01109

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Synonyms

  • NPR2
  • natriuretic peptide receptor 2
  • ANP-B
  • atrial natriuretic peptide receptor B
  • ANPRB
  • atrial natriuretic peptide B-type receptor
  • NPR-B
  • GC-B
  • guanylate cyclase B

General information

  • NPR-B represent one of the five transmembrane guanylyl cyclases found in humans. [1]

Links to other resources

UniProt P20594
Ensembl ENST00000455603

Binding hormones

  • C-type natriuretic peptide
    • The rank order of activation of NPR-B (NPR-2) by natriuretic peptides is CNP ≫ ANP ≥ BNP [1]

Anatomical structures with this receptor

  • chondrocyte

    Induced phenotypes

    • long bone growth
      • CNP-dependent long bone growth requires CNP binding and activation of NPR-2, cGMP binding, and activation of PKGII and PKGII-dependent increases in the proliferation of hypertrophic chondrocytes. [2]
    • NPR-B is expressed in proliferative and prehypertrophic chondrocytes. [2]
  • smooth_muscle_cell

    Induced phenotypes

    • vascular relaxation
      • NPR-B is present in aortic vascular smooth muscle and mediates CNP relaxation of precontracted rat aorta. [1]
    • NPR-B is present in aortic vascular smooth muscle . [1]
Reference