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Details for receptor: CD7

EndoNet ID: ENR01127

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Synonyms

  • Tp41
  • T-cell antigen CD7
  • gp40
  • cluster of differentiation 7 antigen
  • Tp40
  • LEU-9
  • CD7 antigen
  • T-cell leukemia antigen
  • p41 protein
  • CD7

General information

  • Single-domain Ig superfamily molecule expressed on human T and NK cells, as well as on cells in the early stages of T, B, and myeloid cell differentiation. CD7 is highly expressed on malignant immature T cells and is generally absent on malignant mature T cells, such as CD4+ Sezary leukemia and HTLV-1+ adult T-cell leukemia cells. [1]
  • Has a key role in regulating peripheral T and NK cell cytokine production and sensitivity to LPS-induced shock syndromes. [1]
  • Loss of CD7 expression and altered cellular glycosylation contribute to apoptosis resistance of malignant T cells in mycosis fungoides due to the resistance against galectin-1-mediated apoptosis. [2]
  • K12, an epithelial cell secreted protein, was identified as a CD7 ligand. [3]
  • T cell antigen involved in lymphocyte activation and regulation of integrin-mediated adhesion, may play a role in galectin-1-mediated cell death. [4]
  • CD29 and CD7 mediate galectin-3-induced type II T-cell apoptosis. [5]

Links to other resources

UniProt P09564

Subunit information

CD7 antigen

Sequence
AQEVQQSPH CTTVPVGAS VNITCSTSG 
GLRGIYLRQ LGPQPQDII YYEDGVVPT 
TDRRFRGRI DFSGSQDNL TITMHRLQL 
SDTGTYTCQ AITEVNVYG SGTLVLVTE 
EQSQGWHRC SDAPPRASA LPAPPTGSA 
LPDPQTASA LPDPPAASA LPAALAVIS 
FLLGLGLGV ACVLARTQI KKLCSWRDK 
NSAACVVYE DMSHSRCNT LSSPNQYQ

Binding hormones

  • galectin-3
  • galectin-1

Anatomical structures with this receptor

  • peripheral blood leukocytes

  • killer_cell

  • thymocyte

  • B-lymphocyte

  • T-lymphocyte

Reference