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Details for receptor: CD45

EndoNet ID: ENR01128

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  • receptor protein tyrosine phosphatase CD45
  • leukocyte common antigen
  • L-CA
  • CD45 antigen
  • T200
  • CD45

General information

  • N-glycans on CD45 are essential for galectin-1-induced apoptosis of T-cells. [1]
  • CD45 is the prototypic member of transmembrane receptor-like protein tyrosine phosphatases (RPTPs) and has essential roles in immune functions. [2]
  • CD45 is a family of integral membrane tyrosine phosphatase expressed on cells of hemopoietic origin. [1]
  • Lymphocytes express predominantly higher MW isoforms (CD45RA), whereas the majority of thymocytes express the lowest MW structure (CD45RO). [1]

Links to other resources

UniProt P08575
Ensembl ENST00000442510

Binding hormones

  • galectin-1

Anatomical structures with this receptor

  • peripheral blood leukocytes