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Details for receptor: CA125

EndoNet ID: ENR01140

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  • CA125
  • cancer antigen CA125
  • mucin-16
  • ovarian cancer related tumor marker CA125
  • CA-125
  • MUC16

General information

  • Transmembrane glycoprotein that can be released via proteolysis. [1]
  • Mucin-like glycoprotein acting as a galectin-1 receptor. [2]
  • Phosphorylation of the cytoplasmic domain causes extracellular cleavage of the N-terminal domain, which results in the release of soluble fragments into the extracellular space. [2]
  • CA125 expresses specific oligosaccharides that can inhibit the cytotoxicity of human natural killer (NK) cells. [3]

Links to other resources

UniProt Q8WXI7
Ensembl ENST00000397910

Binding hormones

  • galectin-1

Anatomical structures with this receptor