Status
Please wait ...

Details for receptor: CA125

  • Top
  • General information
  • External resources
  • General information
  • Hormones
  • Anatomical structures
  • Click to access the toolbox
EndoNet ID: ENR01140

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • CA125
  • cancer antigen CA125
  • mucin-16
  • ovarian cancer related tumor marker CA125
  • CA-125
  • MUC16

General information

  • Transmembrane glycoprotein that can be released via proteolysis. [1]
  • Mucin-like glycoprotein acting as a galectin-1 receptor. [2]
  • Phosphorylation of the cytoplasmic domain causes extracellular cleavage of the N-terminal domain, which results in the release of soluble fragments into the extracellular space. [2]
  • CA125 expresses specific oligosaccharides that can inhibit the cytotoxicity of human natural killer (NK) cells. [3]

Links to other resources

UniProt Q8WXI7
Ensembl ENST00000397910

Binding hormones

  • galectin-1

Anatomical structures with this receptor

    Reference