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Details for receptor: integrin alpha-6/beta-1

EndoNet ID: ENR01159

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  • integrin alpha-6/beta-1
  • integrin alpha6/beta1
  • integrin alpha6-beta1

General information

  • Proposed to mediate a survival signal received from neurons, a process in which modulation of oligodendrocyte sensitivity to PDGF is implicated. [1]
  • In human hepatocellular carcinoma cells, laminin-binding integrin alpha-6/beta-1 stimulation results in FAK tyrosine phosphorylation, leading to FAK-GRB2 association and ERK cascade activation, which promotes tumor cell migration. [2]

Links to other resources

Subunit information

Integrin alpha-6

UniProt P23229

Integrin beta-1

UniProt P05556

Binding hormones

  • laminin-2
  • laminin-4
  • laminin-5
  • laminin-8
  • laminin-1
  • laminin-10
  • laminin-11
  • CYR61
    • In skin fibroblasts CYR61 binds ITGA6/ITGB1 [3]

Anatomical structures with this receptor

  • oligodendrocyte