Please wait ...

Details for receptor: integrin alpha-6/beta-4

EndoNet ID: ENR01168

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be:

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like
If the search pattern is unambigious the user is directed to the corresponding detail page.


  • integrin alpha-6/beta-4
  • integrin alpha6/beta4
  • integrin alpha6-beta4
  • integrin alpha6beta4

General information

  • Restricts migration and maintains hemidesmosomal integrity.
  • Laminin binding to this receptor results in activation of an associated kinase and consequently tyrosine phosphorylation of the beta-4 subunit cytoplasmic domain, followed by association of the adaptor protein Shc with tyrosine phosphorylated beta-4 integrin subunit. Shc is then phosphorylated, and combines with the adaptor protein Grb2. This leads to Ras activation followed by activation of a kinase cascade consisting of Raf, MEK (MAPK/ERK kinase) and ERK, resulting in increased cell motility and proliferation. [1]
  • Activates the JNK cascade, via Rac1, resulting in jun protein expression. [1]
  • Integrin alpha 6/beta 4 complex is located in hemidesmosomes, suggesting a major role in epidermal cell-basement membrane adhesion. [2]

Links to other resources

Binding hormones

  • laminin-1
  • laminin-10
  • laminin-5
  • laminin-2

Anatomical structures with this receptor

  • keratinocyte