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Details for receptor: netrin receptor UNC5A

EndoNet ID: ENR01170

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  • netrin receptor UNC5A
  • UNC5A
  • Unc-5 homolog A
  • Unc-5 homolog 1
  • UNC5H1

General information

  • UNC5H or DCC, when expressed in the absence of netrin-1, can induce cell death, whereas the presence of netrin-1 is sufficient for blocking this proapoptotic activity. [1]
  • NRAGE, a protein of the MAGE (melanoma antigen) family known to be a regulator of apoptosis, has been identified as a specific binding partner of UNC5H1. The interaction between NRAGE and UNC5H1 could activate the apoptotic pathway by promoting the degradation of the survival protein XIAP (X-linked inhibitor of apoptosis), or by activating the c-Jun N-terminal kinase (JNK) pathway. [1]
  • DCC and the UNC5H proteins regulate apoptosis; positively in the absence of netrin-1, or negatively in the presence of netrin-1. This is designated as the 'dependence receptor' concept. [2]

Links to other resources

UniProt Q6ZN44
Ensembl ENST00000329542

Binding hormones

  • netrin-1
  • netrin-4

Anatomical structures with this receptor