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Details for receptor: netrin receptor UNC5B isoform 2

EndoNet ID: ENR01172

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Synonyms

  • netrin receptor UNC5B isoform 2
  • UNC5H2 isoform 2
  • UNC5H2-isoform2
  • p53-regulated receptor for death and life protein 1 isoform 2
  • p53RDL1 isoform 2
  • Unc-5 homolog 2 isoform 2
  • Unc-5 homolog B isoform 2

General information

  • DCC and the UNC5H proteins regulate apoptosis; positively in the absence of netrin-1, or negatively in the presence of netrin-1. This is designated as the 'dependence receptor' concept. [1]
  • UNC5H or DCC, when expressed in the absence of netrin-1, can induce cell death, whereas the presence of netrin-1 is sufficient for blocking this proapoptotic activity. [2]

Links to other resources

UniProt Q8IZJ1-2
Ensembl ENST00000373192

Binding hormones

  • netrin-1

Anatomical structures with this receptor

    Reference