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Details for receptor: netrin receptor UNC5C

EndoNet ID: ENR01173

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Synonyms

  • netrin receptor UNC5C
  • Unc-5 homolog C
  • Unc-5 homolog 3
  • UNC5H3

General information

  • UNC5H or DCC, when expressed in the absence of netrin-1, can induce cell death, whereas the presence of netrin-1 is sufficient for blocking this proapoptotic activity. [1]
  • DCC and the UNC5H proteins regulate apoptosis; positively in the absence of netrin-1, or negatively in the presence of netrin-1. This is designated as the 'dependence receptor' concept. [2]

Links to other resources

UniProt O95185
Ensembl ENST00000453304

Subunit information

Netrin receptor UNC5C.

Sequence
QDDDFFHEL PETFPSDPP EPLPHFLIE 
PEEAYIVKN KPVNLYCKA SPATQIYFK 
CNSEWVHQK DHIVDERVD ETSGLIVRE 
VSIEISRQQ VEELFGPED YWCQCVAWS 
SAGTTKSRK AYVRIAYLR KTFEQEPLG 
KEVSLEQEV LLQCRPPEG IPVAEVEWL 
KNEDIIDPV EDRNFYITI DHNLIIKQA 
RLSDTANYT CVAKNIVAK RKSTTATVI 
VYVNGGWST WTEWSVCNS RCGRGYQKR 
TRTCTNPAP LNGGAFCEG QSVQKIACT 
TLCPVDGRW TPWSKWSTC GTECTHWRR 
RECTAPAPK NGGKDCDGL VLQSKNCTD 
GLCMQTAPD SDDVALYVG IVIAVIVCL 
AISVVVALF VYRKNHRDF ESDIIDSSA 
LNGGFQPVN IKAARQDLL AVPPDLTSA 
AAMYRGPVY ALHDVSDKI PMTNSPILD 
PLPNLKIKV YNTSGAVSP QDDLSEFTS 
KLSPQMTQS LLENEALSL KNQSLARQT 
DPSCTAFGS FNSLGGHLI VPNSGVSLL 
IPAGAIPQG RVYEMYVTV HRKETMRPP 
MDDSQTLLT PVVSCGPPG ALLTRPVVL 
TMHHCADPN TEDWKILLK NQAAQGQWE 
DVVVVGEEN FTTPCYIKL DAEACHILT 
ENLSTYALV GHSTTKAAA KRLKLAIFG 
PLCCSSLEY SIRVYCLDD TQDALKEIL 
HLERQTGGQ LLEEPKALH FKGSTHNLR 
LSIHDIAHS LWKSKLLAK YQEIPFYHV 
WSGSQRNLH CTFTLERFS LNTVELVCK 
LCVRQVEGE GQIFQLNCT VSEEPTGID 
LPLLDPANT ITTVTGPSA FSIPLPIRQ 
KLCSSLDAP QTRGHDWRM LAHKLNLDR 
YLNYFATKS SPTGVILDL WEAQNFPDG 
NLSMLAAVL EEMGRHETV VSLAAEGQY
UniProt O95185

Binding hormones

  • netrin-1

Anatomical structures with this receptor

    Reference