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Details for receptor: LDL-R

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EndoNet ID: ENR01177

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Synonyms

  • LDLR
  • LDL receptor
  • low-density lipoprotein receptor
  • LDL-R

General information

Links to other resources

UniProt P01130
Ensembl ENST00000455727

Binding hormones

  • APOE
  • proprotein convertase subtilisin/kexin type 9

Anatomical structures with this receptor

  • hepatocyte

    Influences

    • negative apo B-48
      • Apolipoprotein B (apoB) is required for the hepatic assembly and secretion of very low density lipoprotein (VLDL). The LDL receptor (LDLR) promotes post-translational degradation of apoB and thereby reduces VLDL particle secretion. [1]
      • LDLR directs apoB to degradation in a post-ER compartment. Furthermore, the reuptake mechanism of degradation occurs via internalization of apoB through a constitutive endocytic pathway and apoE through a ligand-dependent pathway. [1]
    • negative apo B-100
      • Apolipoprotein B (apoB) is required for the hepatic assembly and secretion of very low density lipoprotein (VLDL). The LDL receptor (LDLR) promotes post-translational degradation of apoB and thereby reduces VLDL particle secretion. [1]
      • LDLR directs apoB to degradation in a post-ER compartment. Furthermore, the reuptake mechanism of degradation occurs via internalization of apoB through a constitutive endocytic pathway and apoE through a ligand-dependent pathway. [1]
Reference